Evidence map›Paper›PMID 34233865›Full record

ArticleBMJ case reports2021

Severe diarrhoea due to use of P2Y12 inhibitor ticagrelor: a rarely reported adverse event.

Khalid Rashid, Muhammad Aamir Waheed, Hafeez Ur Rehman, Abdel-Naser Elzouki

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khalid RashidDepartment of General Medicine, Northampton General Hospital NHS Trust, Northampton, UK Khalidrashid93@gmail.com.
Muhammad Aamir WaheedDepartment of Acute Medicine, Northampton General Hospital, Northampton, UK.
Hafeez Ur RehmanDepartment of Health Sciences, City University of Science and Information Technology, Peshawar, Pakistan.
Abdel-Naser ElzoukiDepartment of Internal Medicine, Hamad Medical Corporation Department of Medical Education, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ticagrelor is a part of dual antiplatelet therapy (DAPT) which has proven benefits in patients with acute coronary syndrome especially in those undergoing percutaneous coronary intervention (PCI). However, like most other drugs, it can lead to undesired and adverse effects such as dyspnoea, easy bruising and gastrointestinal bleeding. We present a case of 70-year-old woman who developed diarrhoea following initiation of DAPT comprising of aspirin and ticagrelor following PCI. After excluding more common causes, it was attributed to ticagrelor administration and completely resolved after it was replaced with another oral antiplatelet agent. On follow-up, the patient reported complete resolution of symptoms.

Indexed as

Acute Coronary SyndromePercutaneous Coronary InterventionAgedDiarrheaFemaleHemorrhageHumansPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTicagrelorPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTicagrelorcardiovascular systemcontraindications and precautionsischaemic heart disease

Identifiers

PMID34233865
PMCPMC8264878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.