Evidence map›Paper›PMID 34233779›Full record

ArticlePalliative & supportive care2022

Development and preliminary evaluation of EMPOWER for surrogate decision-makers of critically ill patients.

Wendy G Lichtenthal, Martin Viola, Madeline Rogers, Kailey E Roberts, Lindsay Lief, Christopher E Cox, Chris R Brewin, Jiehui Cici Xu, Paul K Maciejewski, Cynthia X Pan and 7 more

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Palliative & supportive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05587517 phase2recruitingnot on this map

A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2022 to 2027Enrolled172ConditionsGrief, Trauma, Psychotherapy, Critical CareArmsEMPOWER, Supportive Conversation
NCT06270381 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Empower-Grief: Study Protocol for a Pilot Randomized Controlled Trial

TypeinterventionalSponsorISPA - Instituto Universitario de Ciencias Psicologicas, Sociais e da VidaRan2023 to 2024Enrolled44ConditionsGrief Disorder, ProlongedArmsEMPOWER, Treatment as usual (TAU)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Wendy G LichtenthalDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID https://orcid.org/0000-0003-3597-7826
Martin ViolaCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Madeline RogersDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.
Kailey E RobertsDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.
Lindsay LiefCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Christopher E CoxDepartment of Medicine, Division of Pulmonary & Critical Care Medicine, Duke University School of Medicine, Durham, NC.
Chris R BrewinResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Jiehui Cici XuCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Paul K MaciejewskiCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Cynthia X PanCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.ORCID https://orcid.org/0000-0003-1471-973X
Taylor CoatsDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.
Daniel J OuyangCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Shayna RabinCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Susan C VaughanDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY.
William BreitbartDepartment of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.
Marjorie E MarenbergDepartment of Internal Medicine, University of Pennsylvania, Philadelphia, PA.
Holly G PrigersonCenter for Research on End-of-Life Care, Weill Cornell Medicine, New York, NY.
Cornell University · USMemorial Sloan Kettering Cancer Center · USColumbia University Irving Medical Center · USDuke University · USUniversity College London · GBUniversity of Pennsylvania · USYeshiva University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)R35CA197730 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Holly Gwen Prigerson · 2015 to 2026
$11.2M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
Meaning-Centered Grief Therapy for Parents Bereaved by CancerK07CA172216 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LICHTENTHAL, WENDY G. · 2013 to 2017
$707k
Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) in Caregivers of ICU Cancer PatientsR21CA218313 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LICHTENTHAL, WENDY G., PRIGERSON, HOLLY GWEN · 2017 to 2018
$422k
NCI NIH HHS K07 CA172216NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA218313NCI NIH HHS R35 CA197730NCI NIH HHS T32 CA009461
6 · The paper itself

Abstract

objectiveThe objectives of this study were to develop and refine EMPOWER (Enhancing and Mobilizing the POtential for Wellness and Resilience), a brief manualized cognitive-behavioral, acceptance-based intervention for surrogate decision-makers of critically ill patients and to evaluate its preliminary feasibility, acceptability, and promise in improving surrogates' mental health and patient outcomes.

methodPart 1 involved obtaining qualitative stakeholder feedback from 5 bereaved surrogates and 10 critical care and mental health clinicians. Stakeholders were provided with the manual and prompted for feedback on its content, format, and language. Feedback was organized and incorporated into the manual, which was then re-circulated until consensus. In Part 2, surrogates of critically ill patients admitted to an intensive care unit (ICU) reporting moderate anxiety or close attachment were enrolled in an open trial of EMPOWER. Surrogates completed six, 15-20 min modules, totaling 1.5-2 h. Surrogates were administered measures of peritraumatic distress, experiential avoidance, prolonged grief, distress tolerance, anxiety, and depression at pre-intervention, post-intervention, and at 1-month and 3-month follow-up assessments.

resultsPart 1 resulted in changes to the EMPOWER manual, including reducing jargon, improving navigability, making EMPOWER applicable for a range of illness scenarios, rearranging the modules, and adding further instructions and psychoeducation. Part 2 findings suggested that EMPOWER is feasible, with 100% of participants completing all modules. The acceptability of EMPOWER appeared strong, with high ratings of effectiveness and helpfulness (M = 8/10). Results showed immediate post-intervention improvements in anxiety (d = -0.41), peritraumatic distress (d = -0.24), and experiential avoidance (d = -0.23). At the 3-month follow-up assessments, surrogates exhibited improvements in prolonged grief symptoms (d = -0.94), depression (d = -0.23), anxiety (d = -0.29), and experiential avoidance (d = -0.30). SIGNIFICANCE OF

resultsPreliminary data suggest that EMPOWER is feasible, acceptable, and associated with notable improvements in psychological symptoms among surrogates. Future research should examine EMPOWER with a larger sample in a randomized controlled trial.

Indexed as

Critical IllnessDecision MakingCritical CareGriefHumansIntensive Care UnitsCritical careGriefIntensive care unitInterventionSurrogate decision-making

Identifiers

PMID34233779
PMCPMC8741895
OpenAlexW3182934692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.