Evidence map›Paper›PMID 34233586›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Krüppel-like factor 5-induced overexpression of long non-coding RNA DANCR promotes the progression of cervical cancer via repressing microRNA-145-3p to target ZEB1.

Chunyan Hu, Yu Han, Genhai Zhu, Guifei Li, Xiurong Wu

Abstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Epigenetic Biomarkers for Cervical Cancer Progression: A Scoping Review.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chunyan HuDepartment of Gynaecology, Hainan General Hospital, Haikou, Hainan Province, China.
Yu HanDepartment of Gynaecology, The Fourth People's Hospital of Haikou, Haikou, Hainan Province, China.
Genhai ZhuDepartment of Gynaecology, Hainan General Hospital, Haikou, Hainan Province, China.
Guifei LiDepartment of Gynaecology, Hainan General Hospital, Haikou, Hainan Province, China.
Xiurong WuDepartment of Gynaecology, Hainan General Hospital, Haikou, Hainan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) differentiation antagonizing non-protein coding RNA (DANCR) participates in the development of diverse cancers. Nevertheless, the impact of DANCR on cervical cancer (CC) remains largely unknown. This study aims to explore the effects of DANCR sponging microRNA-145-3p (miR-145-3p) on CC. Expression of KLF5, DANCR, miR-145-3p, and zinc finger E-box binding homeobox 1 (ZEB1) in CC and adjacent normal tissues was determined. Human CC cell lines were, respectively, treated with silenced DANCR or miR145-3p mimic/inhibitor. Then, the viability, migration, invasion, and apoptosis of CC cells were measured. The cell growth

Indexed as

MicroRNAsRNA, Long NoncodingUterine Cervical NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansKruppel-Like Transcription FactorsZinc Finger E-box-Binding Homeobox 1DANCR long noncoding RNA, humanKLF5 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN145 microRNA, humanRNA, Long NoncodingZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1Cervical cancerkrüppel-like factor 5long non-coding RNA differentiation antagonizing non-protein coding RNAMicroRNA-145-3pzinc finger E-box binding homeobox 1

Identifiers

PMID34233586
PMCPMC8344789

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.