Evidence map›Paper›PMID 34233464›Full record

ReviewStroke2021

Acute Stroke Imaging Research Roadmap IV: Imaging Selection and Outcomes in Acute Stroke Clinical Trials and Practice.

Bruce C V Campbell, Maarten G Lansberg, Joseph P Broderick, Colin P Derdeyn, Pooja Khatri, Amrou Sarraj, Jeffrey L Saver, Achala Vagal, Gregory W Albers, STAIR XI Consortium

Open access · bronzeAbstract readReview
In one paragraph

Review in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Outcome prediction value of critical area perfusion score for acute basilar artery occlusion.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Bruce C V Campbell *Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital (B.C.V.C.), University of Melbourne, Parkville, Victoria, Australia.
Maarten G Lansberg *Department of Neurology & Stanford Stroke Center, Stanford University School of Medicine, CA (M.G.L., G.W.A.).
Joseph P BroderickDepartment of Neurology (J.P.B., P.K.), University of Cincinnati, OH.
Colin P DerdeynDepartment of Radiology, Iowa Institute of Biomedical Imaging, University of Iowa Hospitals and Clinics (C.P.D.).
Pooja KhatriDepartment of Neurology (J.P.B., P.K.), University of Cincinnati, OH.
Amrou SarrajUT McGovern Medical School, Department of Neurology, Houston (A.S.).
Jeffrey L SaverDepartment of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California Los Angeles (J.L.S.).
Achala VagalDepartment of Radiology (A.V.), University of Cincinnati, OH.
Gregory W Albers *Department of Neurology & Stanford Stroke Center, Stanford University School of Medicine, CA (M.G.L., G.W.A.).
STAIR XI Consortium
Stanford Medicine · USUniversity of California, Los Angeles · USMount St. Joseph University · USP2D Bioscience (United States) · USThe Royal Melbourne Hospital · AUThe University of Texas Health Science Center · USUniversity of Cincinnati · USUniversity of Iowa Hospitals and Clinics · US

Funding

NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
Making Acute Stroke Trials Succeed: Challenges and Potential SolutionsU01NS110772 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Jordan J. Elm · 2020 to 2026
$24.3M
Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke TrialU01NS100699 · NINDS · WASHINGTON UNIVERSITY · PI ADEOYE, OPEOLU M, BARRETO, ANDREW D · 2018 to 2021
$18.8M
CTP to predict Response to recanalization in Ischemic Stroke Project (CRISP)R01NS075209 · NINDS · STANFORD UNIVERSITY · PI LANSBERG, MAARTEN G · 2011 to 2023
$6.0M
ICH Recovery GrantR01NS100417 · NINDS · UNIVERSITY OF CINCINNATI · PI WOO, DANIEL · 2017 to 2021
$5.3M
DEFUSE 3: EnDovascular ThErapy Following Imaging EvalUation for ISchemic StrokE 3U01NS092076 · NINDS · STANFORD UNIVERSITY · PI ALBERS, GREGORY W · 2015 to 2016
$5.3M
Assessing Population-based Radiological brain health in Stroke Epidemiology (APRISE) StudyR01NS103824 · NINDS · UNIVERSITY OF CINCINNATI · PI KHATRI, POOJA, KISSELA, BRETT M · 2018 to 2022
$3.1M
APRISE Dementia (Assessing Population-based Radiological brain health in Stroke Epidemiology-Dementia)RF1NS117643 · NINDS · UNIVERSITY OF CINCINNATI · PI KHATRI, POOJA, KISSELA, BRETT M · 2020 to 2020
$2.0M
Stanford University Regional Coordinating Stroke Center for the NINDS Stroke TriaU10NS086487 · NINDS · STANFORD UNIVERSITY · PI ALBERS, GREGORY W · 2013 to 2017
$1.9M
NINDS NIH HHS R01 NS075209NINDS NIH HHS R01 NS100417NINDS NIH HHS R01 NS103824NINDS NIH HHS RF1 NS117643NINDS NIH HHS U01 NS086872NINDS NIH HHS U01 NS092076NINDS NIH HHS U01 NS100699NINDS NIH HHS U01 NS110772NINDS NIH HHS U10 NS086487
6 · The paper itself

Abstract

background and purposeThe Stroke Treatment Academic Industry Roundtable (STAIR) sponsored an imaging session and workshop during the Stroke Treatment Academic Industry Roundtable XI via webinar on October 1 to 2, 2020, to develop consensus recommendations, particularly regarding optimal imaging at primary stroke centers.

methodsThis forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss imaging priorities in the light of developments in reperfusion therapies, particularly in an extended time window, and reinvigorated interest in brain cytoprotection trials.

resultsThe imaging session summarized and compared the imaging components of recent acute stroke trials and debated the optimal imaging strategy at primary stroke centers. The imaging workshop developed consensus recommendations for optimizing the acquisition, analysis, and interpretation of computed tomography and magnetic resonance acute stroke imaging, and also recommendations on imaging strategies for primary stroke centers.

conclusionsRecent positive acute stroke clinical trials have extended the treatment window for reperfusion therapies using imaging selection. Achieving rapid and high-quality stroke imaging is therefore critical at both primary and comprehensive stroke centers. Recommendations for enhancing stroke imaging research are provided.

Indexed as

Consensus Statements as TopicClinical Trials as TopicComputed Tomography AngiographyEndovascular ProceduresHumansMagnetic Resonance ImagingStrokeTomography, X-Ray ComputedTreatment Outcomeangiographyclinical trialsischemic strokeperfusion imagingtomography

Identifiers

PMID34233464
PMCPMC8316368
OpenAlexW3180259333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.