ArticleAging2021
Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Comparison of devices used to measure blood pressure, grip strength and lung function: A randomised cross-over study.PloS one · 2023Trial
- Lifetime non-relational traumatic experiences are associated with biological ageing.GeroScience · 2026Article
- Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank.Communications biology · 2026Article
- Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing.BMC medicine · 2026Article
- Influence of lung function on macro- and micro-structural brain changes in mid- and late-life.International journal of surgery (London, England) · 2025Article
- Somatization and Body Composition: Findings from a Cross-Sectional Study on Non-Clinical Young Adults.Healthcare (Basel, Switzerland) · 2025Article
- Metabolomic age (MileAge) predicts health and life span: A comparison of multiple machine learning algorithms.Science advances · 2024Article
- The duration of lithium use and biological ageing: telomere length, frailty, metabolomic age and all-cause mortality.GeroScience · 2024Observational
- Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population.Journal of endocrinological investigation · 2024Article
- Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.BMC medicine · 2024Article
- Body composition, lifestyle, and depression: a prospective study in the UK biobank.BMC public health · 2024Article
- Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder.Biological psychiatry global open science · 2023Article
- Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Weight change across adulthood in relation to the risk of depression.Frontiers in psychology · 2023Article
- Cardiorespiratory fitness and cardiovascular risk among in-patients with depression compared to healthy controls.Frontiers in psychiatry · 2023Article
- Anxiety disorders and age-related changes in physiology.The British journal of psychiatry : the journal of mental science · 2022Article
- Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality.BMC medicine · 2022Article
- Association between level of depression and coronary heart disease, stroke risk and all-cause and cardiovascular mortality: Data from the 2005-2018 National Health and Nutrition Examination Survey.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Individuals with depression, on average, die prematurely, have high levels of physical comorbidities and may experience accelerated biological ageing. A greater understanding of age-related changes in physiology could provide novel biological insights that may help inform strategies to mitigate excess mortality in depression. We used generalised additive models to examine age-related changes in 15 cardiovascular, body composition, grip strength and lung function measures, comparing males and females with a lifetime history of depression to healthy controls. The main dataset included 342,393 adults (mean age = 55.87 years, SD = 8.09; 52.61% females). We found statistically significant case-control differences for most physiological measures. There was some evidence that age-related changes in body composition, cardiovascular function, lung function and heel bone mineral density followed different trajectories in depression. These differences did not uniformly narrow or widen with age and differed by sex. For example, BMI in female cases was 1.1 kg/m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.