ArticleJournal of affective disorders2021
Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder.
Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Estradiol, Emotion Regulation, and the Limbic System: Effects on Gray Matter Volume.Biological psychiatry global open science · 2026Article
- Sex and Hormonal Effects on Drug Cue Reactivity and Its Regulation in Human Addiction.Biological psychiatry · 2026Article
- Unraveling the role of IL-17 signaling pathway in breast cancer-related depression: insights from in vivo/in vitro models and transcriptomic analysis.Functional & integrative genomics · 2026Article
- Gender Differences and Comorbidities in Major Depression.Advances in experimental medicine and biology · 2026Review
- Dark Triad, Depression, Anhedonia and Alexithymia: The Role of Sex Differences.Behavioral sciences (Basel, Switzerland) · 2025Article
- Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats.Frontiers in behavioral neuroscience · 2025Article
- Joint Trajectories of Physical Activity and Depressive Symptoms in Postmenopausal Women in China: A Group-Based Dual Trajectory Analysis of the Five-Year Longitudinal Study.Journal of multidisciplinary healthcare · 2025Article
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular biology reports · 2024Review
- Altered Sexual Response-Related Functional Connectivity and Morphometric Changes Influenced by Sex Hormones across Menopausal Status.Journal of clinical medicine · 2024Article
- Neuroendocrine pathogenesis of perimenopausal depression.Frontiers in psychiatry · 2023Review
- Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.Pharmaceuticals (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEstrogen fluctuations throughout the lifespan may contribute to major depressive disorder (MDD) risk in women through effects on brain networks important in stress responding, and mood regulation. Although there is evidence to support ovarian hormone treatment for peri-menopausal depression, postmenopausal use has not been well examined. The objective of this study was to investigate whether estrogen modulation of the neural and emotional cognitive responses to stress differs between postmenopausal women with and without MDD history.
methods60 postmenopausal women completed an fMRI psychosocial stress task, after receiving no drug or 3 months of daily estradiol (E2). fMRI activity and subjective mood response were examined.
resultsIn women without a history of MDD, E2 was associated with a more negative mood response to stress and less activity in emotional regulation regions. In women with a history of MDD, E2 was associated with a less negative mood response to stress and less activity in emotion perception regions. LIMITATIONS: This study was limited by open-label estradiol administration and inclusion of participants using antidepressants.
conclusionsThese results support a differential effect of estrogen on emotional and neural responses to psychosocial stress in postmenopausal women with MDD history and may reflect a shift in brain activity patterns related to emotion processing following menopause.
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Registered trials
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