ArticleCell2021
GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Erratum issuedOpen access · bronzeAbstract read
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Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 184 papers.
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184citing papers in PubMed
21.0field-weighted citation impact, top 1% of its field
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Who cites it
184 citing papers in PubMed, 297 citations in OpenAlex.
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124 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
17 authors at 3 institutions in 1 country.
Emilia FavuzziDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Shuhan HuangDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Giuseppe A SaldiStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biology, New York University, New York, NY 10003, USA.
Loïc BinanKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Leena A IbrahimDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Marian Fernández-OteroDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Yuqing CaoDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Ayman ZeineDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Adwoa SefahDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Karen ZhengBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Qing XuNew York University Abu Dhabi, Abu Dhabi, UAE.
Elizaveta KhlestovaDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Samouil L FarhiKlarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Richard BonneauDepartment of Biology, New York University, New York, NY 10003, USA; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA; Center for Data Science, New York University, New York, NY 10011, USA.
Sandeep Robert DattaDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Beth StevensStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA 02115, USA.
Gord FishellDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: gordon_fishell@hms.harvard.edu.
Broad Institute · USHarvard University · USFlatiron Health (United States) · US
Funding
The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MACHOLD, ROBERT P · 2012 to 2023
$15.5MRegional and Genetic Diversity of Cortical InterneuronsR01MH071679 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHELL, GORDON J · 2005 to 2020
$8.5MDevelopment and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UG3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2019 to 2021
$6.7MThe Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6MSuper-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8MThe molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1MScaling up spatial RNA profiling with compressed sensingRF1MH121289 · NIMH · BROAD INSTITUTE, INC. · PI CHEN, FEI, ELDAR, YONINA · 2019 to 2019
$1.6MNIMH NIH HHS R01 MH071679NIMH NIH HHS R37 MH071679NIMH NIH HHS RF1 MH121289NIMH NIH HHS UG3 MH120096NINDS NIH HHS P01 NS074972NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS081297
Abstract
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that GABA-receptive microglia selectively interact with inhibitory cortical synapses during a critical window of mouse postnatal development. GABA initiates a transcriptional synapse remodeling program within these specialized microglia, which in turn sculpt inhibitory connectivity without impacting excitatory synapses. Ablation of GABA
Indexed as
AnimalsAnimals, NewbornBehavior, Animalgamma-Aminobutyric AcidGene Expression RegulationHEK293 CellsHumansMiceMicrogliaNeural InhibitionParvalbuminsPhenotypeReceptors, GABA-BSynapsesTranscription, Geneticgamma-Aminobutyric AcidParvalbuminsReceptors, GABA-Bcerebral cortexdevelopmentglia-neuron interactionsinhibitory synapsesinterneuronsmicroglianeurodevelopmental disorders
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