Evidence map›Paper›PMID 34233029›Full record

ArticleThe Laryngoscope2022

Transoral Laser Microsurgery for Glottic Cancer in Patients Over 75 Years Old.

Alberto Paderno, Davide Lancini, Paolo Bosio, Francesca Del Bon, Milena Fior, Giulia Berretti, Marco Alparone, Alberto Deganello, Giorgio Peretti, Cesare Piazza

Open access · hybridAbstract read
In one paragraph

Article in The Laryngoscope, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alberto PadernoUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.ORCID 0000-0002-1621-2142
Davide LanciniUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.ORCID 0000-0002-3525-3118
Paolo BosioUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.
Francesca Del BonUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.
Milena FiorUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.
Giulia BerrettiUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.
Marco AlparoneUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.
Alberto DeganelloUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.ORCID 0000-0003-1008-7333
Giorgio PerettiUnit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.ORCID 0000-0002-2391-9357
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives/hypothesisLaryngeal squamous cell carcinoma (LSCC) has a non-negligible incidence in elderly patients. However, there is still no clear indication on the ideal treatment for early-intermediate glottic LSCC in this specific age group. Both surgical and nonsurgical approaches may be burdened by complications and sequelae that negatively impact patient's health. In this setting, carbon dioxide transoral laser microsurgery (CO STUDY

designRetrospective case series in a single tertiary academic institution.

methodsPatients who underwent CO

resultsA total of 134 patients (mean age, 80 ± 4 years; median, 79; range, 75-93) were included in the study. Seven lesions were classified as pTis, 65 as pT1a, 22 as pT1b, 35 as pT2, and 5 as pT3. No treatment-related death was observed. Twenty-eight (20.9%) patients reported 10 surgical and 19 medical complications. Five-year OS, DSS, RFS, LEDFS, and OP were 68.9%, 95.4%, 79.5%, 66%, and 92.5%, respectively. Age and comorbidities were associated with OS and LEDFS. Advanced T categories were negatively correlated with OS, DSS, RFS, LEDFS, and OP. Age and comorbidities were not significant risk factors for complications.

conclusionsCO LEVEL OF EVIDENCE: 4 Laryngoscope, 132:135-141, 2022.

Indexed as

AgedAged, 80 and overAge FactorsCarcinoma, Squamous CellDisease-Free SurvivalFemaleGlottisHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaser TherapyMaleRetrospective StudiesSurvival AnalysiscomplicationelderlyglottisLaryngeal cancerlaseroncologic outcometransoral surgery

Identifiers

PMID34233029
PMCPMC9291037
OpenAlexW3182990364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.