Evidence map›Paper›PMID 34232860›Full record

ArticleeLife2021

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites.

Zachary K Barth, Maria Ht Nguyen, Kimberley D Seed

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

  1. Molecular Methods to DetectmedRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Why do bacteria accumulate antiphage defence systems?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  8. Review
  9. Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025
    Review
  10. Review
  11. Article
  12. Symbiosis of a lytic bacteriophage andApplied and environmental microbiology · 2024
    Article
  13. Article
  14. March of the proviruses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. AeLife · 2024
    Article
  16. Article
  17. Sporadic phage defense in epidemicbioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. AbioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zachary K BarthDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-1321-306X
Maria Ht NguyenDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-2441-4948
Kimberley D SeedDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-0139-1600
University of California, Berkeley · USChan Zuckerberg Initiative (United States) · US

Funding

Phage resistance and mobile genetic elements in Vibrio choleraeR01AI127652 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI SEED, KIMBERLEY DIANE · 2016 to 2025
$4.6M
Molecular mechanisms driving the coevolution of clinical isolates of phages and epidemic Vibrio choleraeR01AI153303 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Kimberley Diane Seed · 2020 to 2026
$4.3M
High-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0M
Burroughs Wellcome Fund 1019213NIAID NIH HHS R01 AI127652NIAID NIH HHS R01 AI153303NIH HHS S10 OD028685
6 · The paper itself

Abstract

Mobile genetic elements, elements that can move horizontally between genomes, have profound effects on their host's fitness. The

Indexed as

Bacterial ProteinsBacteriophagesCRISPR-Cas SystemsEndonucleasesVibrio choleraeBacterial ProteinsEndonucleasesbacteriophageinfectious diseasemicrobiologymobile elementsatelliteVibrio cholerae

Identifiers

PMID34232860
PMCPMC8263062
OpenAlexW3183004682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.