Evidence map›Paper›PMID 34232841›Full record

Trial reportThe journal of spinal cord medicine2022

Comparison of disc and wire electrodes to restore cough via lower thoracic spinal cord stimulation.

Anthony F DiMarco, Robert T Geertman, Gregory A Nemunaitis, Krzysztof E Kowalski

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of spinal cord medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01659541 (Spinal Cord Stimulation With Wire Leads to Restore Cough), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01659541 nacompletednot on this map

Spinal Cord Stimulation With Wire Leads to Restore Cough

TypeinterventionalSponsorMetroHealth Medical CenterRan2015 to 2021Enrolled12ConditionsSpinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System DiseasesArmsExpiratory muscle stimulator, Implantation of device
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anthony F DiMarcoDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA.
Robert T GeertmanDepartment of Neurosurgery, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA.
Gregory A NemunaitisDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA.
Krzysztof E KowalskiDepartment of Physical Medicine and Rehabilitation, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA.
MetroHealth Medical Center · USCase Western Reserve University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
Evaluation of Spinal Cord Stimulation Using Wire Leads to Restore an Effective CoU01NS083696 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI DIMARCO, ANTHONY F. · 2013 to 2018
$2.7M
Spinal Cord Stimulation to Restore Cough In HumansR01NS049516 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI DIMARCO, ANTHONY F. · 2004 to 2007
$1.4M
NCATS NIH HHS UL1 TR002548NCRR NIH HHS M01 RR000080NCRR NIH HHS UL1 RR024989NINDS NIH HHS R01 NS049516NINDS NIH HHS U01 NS083696
6 · The paper itself

Abstract

objectiveTo compare the safety and effectiveness of wire (WE) vs. disc (DE) electrodes to restore cough in subjects with spinal cord injury (SCI).

designClinical trials assessing the effectiveness and clinical outcomes associated with two electrode systems to activate the expiratory muscles.

settingInpatient hospital setting for DE or WE electrode insertion; outpatient evaluation of cough efficacy and instructions for home use.

participantsTwenty-nine subjects with SCI; 17 participants with DE and 12 with WE implants.

interventionSurgical implantation of WE or DE to restore cough. Daily application of spinal cord stimulation (SCS) at home. MAIN OUTCOME MEASURE(S): Airway pressure (P) and peak airflow (F) generation achieved with SCS; clinical parameters including ease in raising secretions, incidence of acute respiratory tract infections (RTI) and side effects.

resultsP and F achieved with DE and WE were not significantly different. For example, at total lung capacity (TLC) with participant effort, P was 128 ± 12 cmH

conclusionsThe results of this investigation indicate that both DE and WE result in comparable degrees of expiratory muscle activation, clinical benefits and side effects. Importantly, SCS to restore cough can be achieved with use of WE which can be placed using minimally invasive techniques and associated reduction in cost, surgical time and overall risk.

Indexed as

Spinal Cord InjuriesSpinal Cord StimulationCoughElectrodes, ImplantedHumansRespiratory MusclesSpinal CordCoughRehabilitationRespiratory musclesSpinal cord injuryTetraplegia

Identifiers

PMID34232841
PMCPMC9135439
OpenAlexW3177674712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.