Evidence map›Paper›PMID 34232786›Full record

ArticleAntioxidants & redox signaling2021

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development.

Anup Ramachandran, Hartmut Jaeschke

Open access · greenAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Ameliorative effects of aFrontiers in pharmacology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Hepatoprotective and antioxidant effects ofInternational journal of biochemistry and molecular biology · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Delayed treatment with hydro-ethanolic extract ofPharmaceutical science advances · 2024
    Article
  17. Nutrients · 2024
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anup RamachandranDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-5438-2409
Hartmut JaeschkeDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-8695-6980
University of Kansas Medical Center · US

Funding

Nuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1M
Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5M
Autophagy and Drug-Induced Liver InjuryR01DK102142 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING, JAESCHKE, HARTMUT W. · 2014 to 2022
$2.7M
The Immune Response After Drug Induced HepatotoxicityR01DK125465 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI RAMACHANDRAN, ANUP · 2021 to 2025
$1.7M
NIDDK NIH HHS R01 DK102142NIDDK NIH HHS R01 DK125465NIGMS NIH HHS P20 GM103549NIGMS NIH HHS P30 GM118247
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryAnimalsDrug DevelopmentHumansLiverMiceMice, Inbred C57BLOxidantsOxidative StressAcetaminophenOxidantsacetaminophendrug hepatotoxicitymitochondriaNrf2peroxynitritetherapeutic approaches

Identifiers

PMID34232786
PMCPMC8558076
OpenAlexW3178727954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.