Evidence map›Paper›PMID 34232744›Full record

ArticleJournal of virology2021

Fecal Metabolome Signature in the HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Acts as an HIV-1 Antagonist but a

Maike Sperk, Anoop T Ambikan, Shilpa Ray, Kamal Singh, Flora Mikaeloff, Rafael Ceña Diez, Ashwathy Narayanan, Jan Vesterbacka, Piotr Nowak, Anders Sönnerborg and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  11. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Maike SperkDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Anoop T AmbikanDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Shilpa RayDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Kamal SinghChristopher S. Bond Life Sciences Center, University of Missourigrid.134936.a, Columbia, Missouri, USA, 65211, USA.
Flora MikaeloffDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Rafael Ceña DiezDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutegrid.4714.6, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Ashwathy NarayananDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Jan VesterbackaDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutegrid.4714.6, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Piotr NowakDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutegrid.4714.6, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Anders Sönnerborg *Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Ujjwal Neogi *Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutegrid.4714.6, ANA Futura, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEManipal Academy of Higher Education · INUniversity of Missouri · US

Funding

Vetenskapsrådet (VR) 2017-01330Vetenskapsrådet (VR) 2017-05848
6 · The paper itself

Abstract

HIV-1 elite controllers (EC) are a rare group among HIV-1-infected individuals who can naturally control viral replication for a prolonged period. Due to their heterogeneous nature, no universal mechanism could be attributed to the EC status; instead, several host and viral factors have been discussed as playing a role. In this study, we investigated the fecal metabolome and microbiome in a Swedish cohort of EC (

Indexed as

MetabolomeAdultBacteroidaceae InfectionsCase-Control StudiesCD4-Positive T-LymphocytesCohort StudiesDipeptidesFecesFemaleGene Expression ProfilingHIV-1HIV InfectionsHumansMaleMiddle AgedMolecular Docking SimulationDipeptidesantiviral agentsdipeptidesHIV-1 elite controllermetabolomics

Identifiers

PMID34232744
PMCPMC8387056
OpenAlexW3179279869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.