Evidence map›Paper›PMID 34232682›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

The Gut-Arterial Stiffness Axis: Is TMAO a Novel Target to Prevent Age-Related Aortic Stiffening?

Gary L Pierce, Stephen J Roy, Colin J Gimblet

Abstract readEditorialComment
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Gut microbes · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Serum TrimethylamineToxins · 2023
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Gary L PierceDepartment of Health and Human Physiology (G.L.P., S.J.R., C.J.G.), University of Iowa.
Stephen J RoyDepartment of Health and Human Physiology (G.L.P., S.J.R., C.J.G.), University of Iowa.
Colin J GimbletDepartment of Health and Human Physiology (G.L.P., S.J.R., C.J.G.), University of Iowa.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
INTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1M
Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic HypertensionR01AG063790 · NIA · UNIVERSITY OF IOWA · PI PIERCE, GARY L. · 2020 to 2024
$1.7M
NHLBI NIH HHS T32 HL007121NIA NIH HHS R01 AG063790NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Vascular StiffnessAortaMethylaminesMethylaminestrimethyloxamineblood pressurecardiovascular diseasecarotid femoral pulse wave velocityeditorialsmicrobiotatrimethylamine

Identifiers

PMID34232682
PMCPMC8274311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.