Evidence map›Paper›PMID 34232652›Full record

ArticleJournal of agricultural and food chemistry2021

Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.

Anastasia Chrysovalantou Chatziioannou, Eric Benjamins, Linette Pellis, Alfred Haandrikman, Lubbert Dijkhuizen, Sander S van Leeuwen

Abstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Biological Relevance of Goat Milk Oligosaccharides to Infant Health.Journal of agricultural and food chemistry · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anastasia Chrysovalantou ChatziioannouCarbExplore Research BV, Zernikepark 12, 9747 AN Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-1973-7542
Eric BenjaminsAusnutria BV, Dokter van Deenweg 150, 8025 BM Zwolle, The Netherlands.
Linette PellisAusnutria BV, Dokter van Deenweg 150, 8025 BM Zwolle, The Netherlands.
Alfred HaandrikmanAusnutria BV, Dokter van Deenweg 150, 8025 BM Zwolle, The Netherlands.
Lubbert DijkhuizenCarbExplore Research BV, Zernikepark 12, 9747 AN Groningen, The Netherlands.
Sander S van LeeuwenSector Human Nutrition and Health, Department of Laboratory Medicine, University Medical Center Groningen (UMCG), Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-0017-2841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk oligosaccharides (hMOS) are associated with health benefits for newborns. We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate. Potential correlations with factors such as age, parity, and lifetime milk production were examined. An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling. Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples. Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans. Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex. The results significantly contribute to the current understanding of (variations in) gMOS composition.

Indexed as

Milk, HumanOligosaccharidesAnimalsChromatography, High Pressure LiquidFemaleGoatsHumansInfant, NewbornLactationOligosaccharides2′-fucosyllactosegoat milkoligosaccharidessecretorUPLC-FLD

Identifiers

PMID34232652
PMCPMC8383309

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.