Evidence map›Paper›PMID 34232632›Full record

ArticleACS chemical biology2021

Evolution of Polymyxin Resistance Regulates Colibactin Production in

Patric W Sadecki, Samantha J Balboa, Lacey R Lopez, Katarzyna M Kedziora, Janelle C Arthur, Leslie M Hicks

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. TheJournal of proteome research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Current understandings of colibactin regulation.Microbiology (Reading, England) · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Patric W SadeckiDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-0332-3177
Samantha J BalboaDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Lacey R LopezDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Katarzyna M KedzioraDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0001-6524-7731
Janelle C ArthurDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Leslie M HicksDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-8008-3998
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
MOLECULAR AND CELLULAR BIOPHYSICS TRAINING PROGRAMT32GM008570 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A, SLEP, KEVIN C · 1995 to 2022
$5.1M
Microbiota-mediated fibrotic remodeling in the inflamed intestineR01DK124617 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARTHUR, JANELLE C · 2020 to 2024
$1.9M
PepSAVI-MS for discovery of novel botanical antimicrobial peptidesR01GM125814 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HICKS, LESLIE M. · 2018 to 2022
$1.6M
NCI NIH HHS P30 CA016086NIDDK NIH HHS R01 DK124617NIGMS NIH HHS R01 GM125814NIGMS NIH HHS T32 GM008570NIH HHS P40 OD010995
6 · The paper itself

Abstract

The complex reservoir of metabolite-producing bacteria in the gastrointestinal tract contributes tremendously to human health and disease. Bacterial composition, and by extension gut metabolomic composition, is undoubtably influenced by the use of modern antibiotics. Herein, we demonstrate that polymyxin B, a last resort antibiotic, influences the production of the genotoxic metabolite colibactin from adherent-invasive

Indexed as

AnimalsBiological EvolutionCell LineDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsGenes, BacterialMultigene FamilyMutagensPeptidesPeptide SynthasesPolyketidesPolyketide SynthasesPolymyxinsRatsUp-RegulationcolibactinEscherichia coli ProteinsMutagensPeptidesPeptide SynthasesPolyketidesPolyketide SynthasesPolymyxins

Identifiers

PMID34232632
PMCPMC8601121
OpenAlexW3178756210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.