Evidence map›Paper›PMID 34232566›Full record

ArticleEMBO reports2021

The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte.

Eric A Hanse, Min Pan, Wenzhu Liu, Ying Yang, Mari B Ishak Gabra, Thai Q Tran, Xazmin H Lowman, Bryan Ruiz, Qiong A Wang, Mei Kong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Eric A HanseDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-1234-0198
Min PanDepartment of Computational Biology, St. Jude Medical Center, Memphis, TN, USA.
Wenzhu LiuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Ying YangDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Mari B Ishak GabraDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Thai Q TranDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-7559-0525
Xazmin H LowmanDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Bryan RuizDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Qiong A WangDepartment of Molecular Endocrinology, Diabetes and Metabolism Institute, City of Hope Medical Center, Duarte, CA, USA.ORCID 0000-0003-2224-4287
Mei KongDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-8139-2349
University of California, Irvine · USCity Of Hope National Medical Center · USSt. Jude Medical Center · US

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
NCI NIH HHS T32 CA009054
6 · The paper itself

Abstract

Adipose tissue plays a major role in maintaining organismal metabolic equilibrium. Control over the fate decision from mesenchymal stem cells (MSCs) to adipocyte differentiation involves coordinated command of phosphorylation. Protein phosphatase 2A plays an important role in Wnt pathway and adipocyte development, yet how PP2A complexes actively respond to adipocyte differentiation signals and acquire specificity in the face of the promiscuous activity of its catalytic subunit remains unknown. Here, we report the PP2A phosphatase B subunit B56α is specifically induced during adipocyte differentiation and mediates PP2A to dephosphorylate GSK3β, thereby blocking Wnt activity and driving adipocyte differentiation. Using an inducible B56α knock-out mouse, we further demonstrate that B56α is essential for gonadal adipose tissue development in vivo and required for the fate decision of adipocytes over osteoblasts. Moreover, we show B56α expression is driven by the adipocyte transcription factor PPARγ thereby establishing a novel link between PPARγ signaling and Wnt blockade. Overall, our results reveal B56α is a necessary part of the machinery dictating the transition from pre-adipocyte to mature adipocyte and provide fundamental insights into how PP2A complex specifically and actively regulates unique signaling pathway in biology.

Indexed as

Mesenchymal Stem CellsProtein Phosphatase 2AdipocytesAdipogenesisAnimalsCell DifferentiationMicePhosphorylationProtein Phosphatase 2adipocyteB56αPP2APPARγWnt

Identifiers

PMID34232566
PMCPMC8339711
OpenAlexW3180285296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.