ArticleHuman brain mapping2021
White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Dynamic Functional Connectivity Changes in Cortical and Cortico-Striatal Strokes in Mice.CNS neuroscience & therapeutics · 2026Article
- Cerebellar Tracts Microstructural Characteristics and Severity of Language Impairment in Post-stroke Patients with Aphasia: A DTI Study.Cerebellum (London, England) · 2026Article
- Structural connectome changes as biomarkers of stroke recovery: a longitudinal 7T MRI study.BMC neuroscience · 2026Article
- Brain changes in stroke patients during rehabilitation: a longitudinal study.Frontiers in neuroscience · 2025Article
- Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.Brain communications · 2025Article
- Analysis of the impact of cerebral small vessel disease on neurological outcomes in patients with basal ganglia/corona radiata ischemic stroke treated with intravenous thrombolysis under multimodal MRI guidance.Frontiers in neurology · 2025Article
- Topological functional network analysis of cortical blood flow in hyperacute ischemic rats.Brain structure & function · 2024Article
- Structural Brain Network Abnormalities in Parkinson's Disease With Freezing of Gait.Frontiers in aging neuroscience · 2022Article
- White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions.Human brain mapping · 2021Article
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10 authors.
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Abstract
Diffusion tensor imaging (DTI) studies have revealed distinct white matter (WM) characteristics of the brain following diseases. Beyond the lesion-symptom maps, stroke is characterized by extensive structural and functional alterations of brain areas remote to local lesions. Here, we further investigated the structural changes over a global level by using DTI data of 10 ischemic stroke patients showing motor impairment due to basal ganglia lesions and 11 healthy controls. DTI data were processed to obtain fractional anisotropy (FA) maps, and multivariate pattern analysis was used to explore brain regions that play an important role in classification based on FA maps. The WM structural network was constructed by the deterministic fiber-tracking approach. In comparison with the controls, the stroke patients showed FA reductions in the perilesional basal ganglia, brainstem, and bilateral frontal lobes. Using network-based statistics, we found a significant reduction in the WM subnetwork in stroke patients. We identified the patterns of WM degeneration affecting brain areas remote to the lesions, revealing the abnormal organization of the structural network in stroke patients, which may be helpful in understanding of the neural mechanisms underlying hemiplegia.
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