Evidence map›Paper›PMID 34232474›Full record

ArticleInterdisciplinary sciences, computational life sciences2021

Using Network Distance Analysis to Predict lncRNA-miRNA Interactions.

Li Zhang, Pengyu Yang, Huawei Feng, Qi Zhao, Hongsheng Liu

Abstract read
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Article in Interdisciplinary sciences, computational life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed.

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  4. lncRNA TUG1 and kidney diseases.BMC nephrology · 2025
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  14. Predicting circRNA-RBP Binding Sites Using a Hybrid Deep Neural Network.Interdisciplinary sciences, computational life sciences · 2024
    Article
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  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li ZhangSchool of Life Science, Liaoning University, Shenyang, 110036, China.
Pengyu YangSchool of Information, Liaoning University, Shenyang, 110036, China.
Huawei FengSchool of Life Science, Liaoning University, Shenyang, 110036, China.
Qi ZhaoSchool of Computer Science and Software Engineering, University of Science and Technology Liaoning, Anshan, 114051, China. zhaoqi@lnu.edu.cn.ORCID http://orcid.org/0000-0001-9713-1864
Hongsheng LiuResearch Center for Computer Simulating and Information Processing of Bio-Macromolecules of Shenyang, Liaoning University, Shenyang, 110036, China. liuhongsheng@lnu.edu.cn.

Funding

Key R&D Program of Liaoning Province 2019JH2/10300041National Natural Science Foundation of China 82003655Scientific Research Project from Department of Education of Liaoning Province LQN201906Shenyang Science and Technology Plan Project 17-65-7-00Shenyang Science and Technology Plan Project 20-203-6-00
6 · The paper itself

Abstract

LncRNA-miRNA interactions contribute to the regulation of therapeutic targets and diagnostic biomarkers in multifarious human diseases. However, it remains difficult to experimentally identify lncRNA-miRNA associations at large scale, and computational prediction methods are limited. In this study, we developed a network distance analysis model for lncRNA-miRNA association prediction (NDALMA). Similarity networks for lncRNAs and miRNAs were calculated and integrated with Gaussian interaction profile (GIP) kernel similarity. Then, network distance analysis was applied to the integrated similarity networks, and final scores were obtained after confidence calculation and score conversion. Our model obtained satisfactory results in fivefold cross validation, achieving an AUC of 0.8810 and an AUPR of 0.8315. Moreover, NDALMA showed superior prediction performance over several other network algorithms, and we tested the suitability and flexibility of the model by comparing different types of similarity. In addition, case studies of the relationships between lncRNAs and miRNAs were conducted, which verified the reliability of our method in predicting lncRNA-miRNA associations. The datasets and source code used in this study are available at https://github.com/Liu-Lab-Lnu/NDALMA .

Indexed as

AlgorithmsComputational BiologyHumansMicroRNAsReproducibility of ResultsRNA, Long NoncodingMicroRNAsRNA, Long NoncodingInteraction predictionlncRNAmiRNANetwork distance

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.