Evidence map›Paper›PMID 34232472›Full record

ArticleJournal of neuro-oncology2021

NIH funding trends for neurosurgeon-scientists from 1993-2017: Biomedical workforce implications for neurooncology.

Karim ReFaey, William D Freeman, Shashwat Tripathi, Hugo Guerrero-Cazares, Tiffany A Eatz, James F Meschia, Rickey E Carter, Leonard Petrucelli, Fredric B Meyer, Alfredo Quinones-Hinojosa

Abstract read
In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karim ReFaey *Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
William D Freeman *Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Shashwat TripathiDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Hugo Guerrero-CazaresDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Tiffany A EatzUniversity of Miami, Miller School of Medicine, Miami, FL, USA.
James F MeschiaDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Rickey E CarterDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Fredric B MeyerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Alfredo Quinones-HinojosaDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA. Quinones-Hinojosa.Alfredo@mayo.edu.ORCID http://orcid.org/0000-0003-4262-5968

Funding

Intra-Operative, Label-Free Detection of Brain Cancer Infiltration with Quantitative Optical ImagingR01CA200399 · NCI · JOHNS HOPKINS UNIVERSITY · PI LI, XINGDE, QUINONES-HINOJOSA, ALFREDO · 2016 to 2020
$3.0M
Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationR01NS070024 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2010 to 2014
$2.4M
A novel microfluidic device to predict brain cancer prognosis and response to therapyR01CA216855 · NCI · MAYO CLINIC JACKSONVILLE · PI KONSTANTOPOULOS, KONSTANTINOS, QUINONES-HINOJOSA, ALFREDO · 2018 to 2022
$2.4M
Nanoparticle Modified Human Fat Derived Mesenchymal Stem Cells for Brain Cancer (Change of Organization Application)R01CA195503 · NCI · MAYO CLINIC JACKSONVILLE · PI GREEN, JORDAN, QUINONES-HINOJOSA, ALFREDO · 2016 to 2020
$1.9M
BMP4 Engineered Mesenchymal Stem Cell Therapy for GlioblastomaR01CA183827 · NCI · MAYO CLINIC JACKSONVILLE · PI QUINONES-HINOJOSA, ALFREDO · 2015 to 2019
$1.9M
Dynamics and Causal Functions of Large-Scale Cortical and Subcortical NetworksU01NS108916 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 2018 to 2019
$1.4M
Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer using Pathology BiopsiesR33CA240181 · NCI · PURDUE UNIVERSITY · PI CHAICHANA, KAISORN LEE, COOKS, ROBERT GRAHAM · 2020 to 2021
$771k
Chemically produced neural progenitors as a delivery vehicle for anti-glioma therapyR43CA221490 · NCI · CELL REPROGRAMMING AND THERAPEUTICS, LLC · PI ALEXANIAN, ARSHAK R, QUINONES-HINOJOSA, ALFREDO · 2018 to 2018
$300k
NCI NIH HHS 1R43CA221490-01A1NCI NIH HHS 5R01CA195503-06NCI NIH HHS 5R01CA200399-05NCI NIH HHS 5R01CA216855-03NCI NIH HHS R01 CA183827NCI NIH HHS R01 CA195503NCI NIH HHS R01 CA200399NCI NIH HHS R01 CA216855NCI NIH HHS R33 CA240181NCI NIH HHS R43 CA221490NINDS NIH HHS 7U01NS108916-03NINDS NIH HHS R01 NS070024
6 · The paper itself

Abstract

introductionNeurosurgeons represent 0.5% of all physicians and currently face a high burden of disease. Physician-scientists are essential to advance the mission of National Academies of Science (NAS) and National Institutes of Health (NIH) through discovery and bench to bedside translation. We investigated trends in NIH neurosurgeon-scientist funding over time as an indicator of physician-scientist workforce training.

methodsWe used NIH Research Portfolio Online Reporting Tools (RePORTER) to extract grants to neurosurgery departments and neurosurgeons from 1993 to 2017. Manual extraction of each individual grant awardee was conducted.

resultsAfter adjusting for U.S. inflation (base year: 1993), NIH funding to neurosurgery departments increased yearly (P < 0.00001). However, neurosurgeon-scientists received significantly less NIH funding compared to scientists (including basic scientists and research only neurosurgeons) (P = 0.09). The ratio of neurosurgeon-scientists to scientists receiving grants was significantly reduced (P = 0.002). Interestingly, the percentage of oncology-related neurosurgery grants significantly increased throughout the study period (P = 0.002). The average number of grants per neurosurgeon-scientists showed an upward trend (P < 0.001); however, the average number of grants for early-career neurosurgeon-scientists, showed a significant downward trend (P = 0.05).

conclusionOver the past 23 years, despite the overall increasing trends in the number of NIH grants awarded to neurosurgery departments overall, the proportion of neurosurgeon-scientists that were awarded NIH grants compared to scientists demonstrates a declining trend. This observed shift is disproportionate in the number of NIH grants awarded to senior level compared to early-career neurosurgeon-scientists, with more funding allocated towards neurosurgical-oncology-related grants.

Indexed as

Biomedical ResearchNational Institutes of Health (U.S.)NeurosurgeonsResearch Support as TopicHealth WorkforceHumansMedical OncologyNeurologyUnited StatesClinician-scientistFundingNational Institutional of Health (NIH) funding to neuro-surgeryNeurosurgeon-ScientistResearchTraining

Identifiers

PMID34232472
PMCPMC8684039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.