Evidence map›Paper›PMID 34232411›Full record

ReviewCurrent allergy and asthma reports2021

Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis.

Joana Caiado, Mariana C Castells

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Combination Gadolinium Angiography and Intravascular Ultrasound Study for Coronary Artery and Graft Assessment.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  4. Rates of paclitaxel hypersensitivity reactions using a modified Markman's infusion protocol as primary prophylaxis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  5. Article
  6. Article
  7. Immune Reactions in Major Types of Oncological Treatment.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Utilizing Biologics in Drug Desensitization.Current allergy and asthma reports · 2023
    Review
  10. Desensitization for the prevention of drug hypersensitivity reactions.The Korean journal of internal medicine · 2022
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Joana CaiadoImmunoallergology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Av. Professor Egas Moniz, 1649-035, Lisbon, Portugal. joanacaiado@hotmail.com.ORCID 0000-0003-3401-7903
Mariana C CastellsDivision of Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypersensitivity reactions (HSRs) to antineoplastic drugs are increasing due to the expanding use of classical and new drugs in a wide variety of malignancies. PURPOSE OF REVIEW: The goal of this review is to provide current best practices in the diagnosis and management of HSRs based on data and evidence. RECENT

findingsA plethora of studies have provided evidence of the safety and efficacy of rapid drug desensitizations (RDD) to allow for the reintroduction of antineoplastic drugs following an HSR, based on risk stratification. Recently described biomarkers such as basophil activation test, total IgE, BRCA genotyping, and serum IL-6 can aid in guiding improved precision desensitization protocols. Personalized premedication regimens and protocols have improved RDD safety and outcomes. RDD allows for the continued use of chemotherapeutic drugs without impaired drug efficacy. RDD represents the best approach to maintain cancer patients on their most effective treatments.

Indexed as

AnaphylaxisAntineoplastic AgentsDrug HypersensitivityPharmaceutical PreparationsDesensitization, ImmunologicHumansAntineoplastic AgentsPharmaceutical PreparationsChemotherapyEndophenotypesHypersensitivity reactionsMonoclonal antibodiesRapid drug desensitizationRisk stratification

Identifiers

PMID34232411
OpenAlexW3181732986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.