Evidence map›Paper›PMID 34232401›Full record

ArticleWorld journal of microbiology & biotechnology2021

Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates.

A Shcherbakova, A A Strömstedt, U Göransson, O Gnezdilov, A Turanov, D Boldbaatar, D Kochkin, G Ulrich-Merzenich, A Koptina

Abstract read
In one paragraph

Article in World journal of microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Unassuming Lichens: Nature's Hidden Antimicrobial Warriors.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Phytochemical combinations of lichenFrontiers in pharmacology · 2025
    Article
  7. Eco-Friendly SpeciesACS omega · 2024
    Article
  8. Article
  9. GC-MS Profiling and Pharmacological Potential ofTurkish journal of pharmaceutical sciences · 2024
    Article
  10. Pleiotropic Potential ofMolecules (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Effects of the Dibenzofuran, Usnic Acid, on Inhibition of Ocular Biofilm Formation Due to Coagulase-Negative Staphylococci.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Lichen Polyphenolic Compounds for the Eradication ofFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A ShcherbakovaVolga State University of Technology, Lenin Sq., 3, Yoshkar-Ola, Russia, 424000.
A A StrömstedtPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, 751 24, Uppsala, Sweden.
U GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, 751 24, Uppsala, Sweden.
O GnezdilovFRC Kazan Scientific Center, Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Sibirsky Tract, 10/7, Kazan, Russia, 420029.
A TuranovFRC Kazan Scientific Center, Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Sibirsky Tract, 10/7, Kazan, Russia, 420029.
D BoldbaatarPharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, 751 24, Uppsala, Sweden.
D KochkinFaculty of Biology, Lomonosov Moscow State University, GSP-1, 1-12 Leninskiye Gory, Moscow, Russia, 119234.
G Ulrich-Merzenich *Medical Clinic III, AG Synergy Research and Experimental Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
A Koptina *Pharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, 751 24, Uppsala, Sweden. avkoptina@gmail.com.ORCID http://orcid.org/0000-0002-1249-8876

Funding

Federal Agency of Atomic Energy of the Russian Federation (RU) MK5290.2012.4
6 · The paper itself

Abstract

Lichens are symbiotic organisms formed by a fungus and one or more photosynthetic partners which are usually alga or cyanobacterium. Their diverse and scarcely studied metabolites facilitate adaptability to extreme living conditions. We investigated Evernia prunastri (L.) Ach., a widely distributed lichen, for its antimicrobial and antioxidant potential. E. prunastri was sequentially extracted by hexane (Hex), dichloromethane (DCM) and acetonitrile (ACN) that were screened for their antioxidant and antimicrobial (against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans) activities. The Hex extract possessed the highest antioxidant capacity (87 mg ascorbic acid/g extract) corresponding to the highest content of phenols (73 mg gallic acid/g extract). The DCM and Hex extracts were both active against S. aureus (MICs of 4 and 21 µg/ml, respectively) but were less active against Gram-negative bacteria and yeast. The ACN extract exhibited activity on both S. aureus (MIC 14 µg/ml) and C. albicans (MIC 38 µg/ml) and was therefore further fractionated by silica gel column chromatography. The active compound of the most potent fraction was subsequently characterized by

Indexed as

Anti-Infective AgentsAntioxidantsBacteriaCandida albicansMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsParmeliaceaePlant ExtractsAnti-Infective AgentsAntioxidantsPlant ExtractsAntimicrobial activityAnti-oxidative activityEvernia prunastri (L.) Ach.Evernic acidLichenUsnic acid

Identifiers

PMID34232401
PMCPMC8263414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.