Evidence map›Paper›PMID 34232083›Full record

ArticlemSphere2021

Molecular Epidemiology of Drug-Resistant Mycobacterium Tuberculosis in Japan.

Fuminori Mizukoshi, Nobuyuki Kobayashi, Fumiko Kirikae, Ken Ohta, Kazunari Tsuyuguchi, Noritaka Yamada, Yoshikazu Inoue, Masahide Horiba, Noriko Kawata, Akiko Ichinose and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Isolation and identification ofFrontiers in cellular and infection microbiology · 2024
    Article
  4. Whole-Genome Sequencing ofMicroorganisms · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Fuminori MizukoshiTochigi Prefectural Institute of Public Health and Environmental Science, Utsunomiya, Tochigi, Japan.
Nobuyuki KobayashiDepartment of Respiratory Medicine, National Hospital Organization (NHO) Tokyo National Hospital, Kiyose, Tokyo, Japan.
Fumiko KirikaeDepartment of Microbiology, Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.
Ken OhtaDepartment of Respiratory Medicine, National Hospital Organization (NHO) Tokyo National Hospital, Kiyose, Tokyo, Japan.
Kazunari TsuyuguchiClinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan.
Noritaka YamadaDepartment of Respiratory Medicine, NHO Higashinagoya National Hospital, Nagoya, Aichi, Japan.
Yoshikazu InoueClinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan.
Masahide HoribaDepartment of Respiratory Medicine, NHO Higashisaitama National Hospital, Hasuda, Saitama, Japan.
Noriko KawataDepartment of Allergy and Respiratory Medicine, NHO Minami-Okayama Medical Center, Tsukubo, Okayama, Japan.
Akiko IchinoseDepartment of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan.
Tohru Miyoshi-AkiyamaDepartment of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
Reiko KiritaniTochigi Prefectural Institute of Public Health and Environmental Science, Utsunomiya, Tochigi, Japan.
Keiji FunatogawaTochigi Prefectural Institute of Public Health and Environmental Science, Utsunomiya, Tochigi, Japan.
Teruo KirikaeDepartment of Microbiology, Faculty of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.
Tochigi Prefectural Police · JPJuntendo University · JPNHO Kinki Chuo Chest Medical Center · JPHakodate National Hospital · JPHigashi Nagoya National Hospital · JPJapan Anti Tuberculosis Association · JPNational Center for Global Health and Medicine · JPOkayama Medical Center · JPTokyo National Hospital · JPWaseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical isolates of drug-resistant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients were approximately 32% of all 795 patients who were diagnosed with culture-confirmed drug-resistant tuberculosis from 2015 to 2016 nationwide in Japan. The whole-genome sequences of all the isolates from the 254 patients and the lineages of these isolates were determined, and phylogenetic trees were constructed based on single nucleotide polymorphism concatemers. Of these patients, 202 (79.5%) were born in Japan and 52 (20.5%) were born elsewhere. Of the 254 drug-resistant isolates, 54 (21.3%) were multidrug resistant, being resistant to both isoniazid and rifampicin. The percentages of multidrug-resistant isolates were significantly higher in foreign-born (38.5% [20/52]) than Japanese-born patients (16.8% [34/202]). Of the 54 multidrug-resistant isolates, nine were extensively drug resistant, which were all obtained from Japanese-born patients. Five extensively drug-resistant isolates were obtained from patients with incipient tuberculosis. A significant number of multidrug-resistant M. tuberculosis strains were isolated from foreign-born patients from Asian countries that have a high tuberculosis burden. Foreign-derived isolates affect the nationwide genetic diversity of drug-resistant M. tuberculosis in Japan. Extensively drug-resistant M. tuberculosis isolates were transmitted among the Japanese population.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibiotics, AntitubercularDNA, BacterialDrug Resistance, Multiple, BacterialEmigrants and ImmigrantsEpidemiological MonitoringFemaleGenome, BacterialHumansJapanMaleMicrobial Sensitivity TestsMiddle AgedAntibiotics, AntitubercularDNA, BacterialRifampindrug-resistant M. tuberculosisforeign bornJapanwhole-genome sequencing

Identifiers

PMID34232083
PMCPMC8386464
OpenAlexW3179825299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.