Evidence map›Paper›PMID 34232073›Full record

ArticlemSphere2021

Distribution of Antimicrobial Resistance and Virulence Genes within the Prophage-Associated Regions in Nosocomial Pathogens.

Kohei Kondo, Mitsuoki Kawano, Motoyuki Sugai

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A phage takes the wheel.Nature microbiology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Prophage typing ofIranian journal of microbiology · 2026
    Article
  10. Article
  11. Review
  12. Extensive hidden prophage diversity inMicrobiology (Reading, England) · 2026
    Article
  13. Article
  14. Prophage diversity in poultry-associatedFrontiers in microbiology · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Dark Matter Carried byInternational journal of molecular sciences · 2025
    Article
  19. Comparative genomics ofJournal of bacteriology · 2025
    Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kohei KondoAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Tokyo, Japan.
Mitsuoki KawanoDepartment of Human Nutrition, Faculty of Contemporary Life Science, Chugokugakuen University, Kita-ku, Okayama, Japan.
Motoyuki SugaiAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Tokyo, Japan.
National Institute of Infectious Diseases · JPChugoku Gakuen University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prophages are often involved in host survival strategies and contribute toward increasing the genetic diversity of the host genome. Prophages also drive horizontal propagation of various genes as vehicles. However, there are few retrospective studies contributing to the propagation of antimicrobial resistance (AMR) and virulence factor (VF) genes by prophage. We extracted the complete genome sequences of seven pathogens, including ESKAPE bacteria and Escherichia coli from a public database, and examined the distribution of both the AMR and VF genes in prophage-like regions. We found that the ratios of AMR and VF genes greatly varied among the seven species. More than 70% of Enterobacter cloacae strains had VF genes, but only 1.2% of Klebsiella pneumoniae strains had VF genes from prophages. AMR and VF genes are unlikely to exist together in the same prophage region except in

Indexed as

Anti-Bacterial AgentsBacteriaCross InfectionDrug Resistance, BacterialEnterobacter cloacaeEscherichia coliGenome, BacterialHumansKlebsiella pneumoniaeProphagesVirulenceVirulence FactorsAnti-Bacterial AgentsVirulence Factorsantimicrobial resistancenosocomial pathogenprophageprophage-like elementvirulence factors

Identifiers

PMID34232073
PMCPMC8386436
OpenAlexW3177694489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.