ArticleJournal of virology2021
Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
Open access · greenAbstract read
In one paragraph
Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- mGem: Opening Env and harnessing NK cell effector functions to eliminate HIV-1-infected cells.mBio · 2026Review
- LC-MS/MS method for quantifying the HIV-1 broadly neutralizing antibody PGT 121.414.LS in human serum.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2025Article
- Review
- Fc mutagenesis enhances the functionality of anti-RhD monoclonal antibodies.Blood advances · 2025Article
- Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.Plant biotechnology journal · 2025Article
- Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing.Communications biology · 2024Article
- Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity.Cell reports · 2023Article
- Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control.Frontiers in immunology · 2022Review
- A new flow cytometry assay to measure antibody-dependent cellular cytotoxicity against SARS-CoV-2 Spike-expressing cells.STAR protocols · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 3 countries.
Sai Priya Anand *Centre de Recherche du CHUM, Montreal, Quebec, Canada.
Shilei Ding *Centre de Recherche du CHUM, Montreal, Quebec, Canada.
William D TolbertInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciencesgrid.265436.0, Bethesda, Maryland, USA.
Jérémie PrévostCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Jonathan RichardCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Hwi Min GilWisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA.
Gabrielle Gendron-LepageCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Wing-Fai CheungPlantForm Corporation, Toronto, Ontario, Canada.
Haifeng WangPlantForm Corporation, Toronto, Ontario, Canada.
Rebecca PastoraPlantForm Corporation, Toronto, Ontario, Canada.
Hirak SaxenaDepartment of Chemistry and Biology, Ryerson Universitygrid.68312.3e, Toronto, Ontario, Canada.
Warren WakarchukDepartment of Chemistry and Biology, Ryerson Universitygrid.68312.3e, Toronto, Ontario, Canada.
Halima MedjahedCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Bruce D WinesImmune Therapies Group, Burnet Institutegrid.1056.2, Melbourne, VIC, Australia.
Mark HogarthImmune Therapies Group, Burnet Institutegrid.1056.2, Melbourne, VIC, Australia.
George M ShawDepartments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Malcom A MartinLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dennis R BurtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.
Lars HangartnerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.
David T EvansWisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA.
Marzena PazgierInfectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciencesgrid.265436.0, Bethesda, Maryland, USA.
Doug CossarPlantForm Corporation, Toronto, Ontario, Canada.
Michael D McLeanPlantForm Corporation, Toronto, Ontario, Canada.
Andrés FinziCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Centre Hospitalier de l’Université de Montréal · CABurnet Institute · AUScripps Research Institute · USToronto Metropolitan University · CAUniformed Services University of the Health Sciences · USUniversity of Wisconsin–Madison · USNational Institutes of Health · USUniversity of Pennsylvania · US
Funding
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6MX-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6MPhysical Resources CoreP01AI120756 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2016 to 2020
$17.1MDissecting Polyclonal Sera to Reveal Correlates of Productive Immune Responses to HIVR01AI136621 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Lars Oliver Hangartner, Andrew Barrett Ward · 2018 to 2026
$8.0MUnderstanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01AI150471 · NIAID · DREXEL UNIVERSITY · PI HENDRICKSON, WAYNE A. · 2019 to 2022
$7.8MSustained antibody delivery for durable suppression of immunodeficiency virus replicationR01AI121135 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2015 to 2026
$6.9MKIR and MHC Class I Immunogenetics in SIV InfectionR37AI095098 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2019 to 2026
$5.6MAssessing ADCC and Fc-mediated Protection against HIVR01AI148379 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T, FINZI, ANDRES · 2019 to 2023
$3.8MHarnessing adaptive NK cell transfer to deplete viral reservoirsR01AI161816 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BARKER, EDWARD, EVANS, DAVID T · 2021 to 2025
$3.8MTethering lentiviral restriction to Fc-mediated antibody responsesR01AI155163 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI EVANS, DAVID T · 2020 to 2024
$3.2MUnlocking Envelope: A New Strategy for a Functional Cure Through Antibody-Dependent Cell-Mediated CytotoxicityR01AI129769 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2017 to 2021
$2.3MStructural Targeting of Potentially Protective gp120 Epitopes in the C1/C2 RegionR01AI116274 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2016 to 2019
$1.5MNIAID NIH HHS P01 AI120756NIAID NIH HHS P01 AI150471NIAID NIH HHS R01 AI116274NIAID NIH HHS R01 AI121135NIAID NIH HHS R01 AI129769NIAID NIH HHS R01 AI136621NIAID NIH HHS R01 AI148379NIAID NIH HHS R01 AI155163NIAID NIH HHS R01 AI161816NIAID NIH HHS R37 AI095098NIAID NIH HHS UM1 AI144462NIGMS NIH HHS P30 GM133893
Abstract
The activity of broadly neutralizing antibodies (bNAbs) targeting HIV-1 depends on pleiotropic functions, including viral neutralization and the elimination of HIV-1-infected cells. Several
Indexed as
Antibodies, MonoclonalAntibodies, NeutralizingAntibody-Dependent Cell CytotoxicityCD4-Positive T-LymphocytesGlycosylationHIV-1HIV AntibodiesHIV InfectionsHumansNicotianaPolysaccharidesAntibodies, MonoclonalAntibodies, NeutralizingHIV AntibodiesPolysaccharidesADCCbroadly neutralizing antibodiesEnvelope glycoproteinsEnv glycoproteinsFcγRIIIafucosegalactoseglycosylationHIV-1neutralizing antibodiesNicotiana benthamianaPGT121plant antibodies
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.