Evidence map›Paper›PMID 34232063›Full record

ArticleJournal of virology2021

CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice.

Chandra N Roy, Mariana A Benitez Moreno, Chris Kline, Zandrea Ambrose

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Reporter-expressing viruses for antiviral drug discovery research.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chandra N RoyDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.
Mariana A Benitez MorenoDepartment of Infectious Diseases and Microbiology, University of Pittsburghgrid.21925.3d Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Chris KlineDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.
Zandrea AmbroseDepartment of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8610-2766
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Visualization of in vivo HIV-1 vaginal transmission in the presence and absence of PrEPR01AI116276 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSE, ZANDREA · 2015 to 2019
$2.9M
HHS | National Institutes of Health (NIH) AI116276HHS | National Institutes of Health (NIH) CA047904NCI NIH HHS P30 CA047904NIAID NIH HHS R01 AI116276
6 · The paper itself

Abstract

Visualizing the transmission and dissemination of human immunodeficiency virus type 1 (HIV-1) in real time in humanized mouse models is a robust tool to investigate viral replication during treatments and in tissue reservoirs. However, the stability and expression of HIV-1 reporter genes are obstacles for long-term serial imaging

Indexed as

Genes, ReporterVirus ReplicationAnimalsCD4-Positive T-LymphocytesDinucleoside PhosphatesGene ExpressionHIV-1HIV InfectionsHumansLuciferasesLuminescent MeasurementsLuminescent ProteinsMiceOptical ImagingViremiaWhole Body ImagingCpG dinucleotideDinucleoside PhosphatesLuciferasesLuminescent Proteinsanimal modelsantiretroviral therapyhuman immunodeficiency virusin vivo imagingreporter virusesviral reservoir

Identifiers

PMID34232063
PMCPMC8428378
OpenAlexW3182008660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.