Evidence map›Paper›PMID 34231973›Full record

ArticleCancer reports (Hoboken, N.J.)2022

Cognitive, language, and school performance in children and young adults treated for low-grade astrocytoma in the posterior fossa in childhood.

Ingela Kristiansen, Cristina Eklund, Margareta Strinnholm, Bo Strömberg, Maria Törnhage, Per Frisk

Open access · goldAbstract read
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ingela KristiansenDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.ORCID 0000-0002-7241-6035
Cristina EklundDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.
Margareta StrinnholmDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.
Bo StrömbergDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.
Maria TörnhageDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.
Per FriskDepartment of Women's and Children's Health, Uppsala University and Uppsala University Children's Hospital, Uppsala, Sweden.
Uppsala University Hospital · SE

Funding

BarncancerfondenGillbergska stiftelsenHedström foundation
6 · The paper itself

Abstract

backgroundPilocytic astrocytoma is the most common brain tumour type in childhood located in the posterior fossa, and treated mainly with surgery. These tumours have low mortality, but knowledge concerning its long-term outcome is sparse.

aimThe aim of this study was to investigate whether children treated for pilocytic astrocytoma in the posterior fossa had late complications affecting cognition, language and learning.

methodsThis descriptive single-centre study includes eight children and 12 adults treated as children for pilocytic astrocytoma in the posterior fossa, with a mean follow-up time of 12.4 (range 5-19) years. Well-established tests of intelligence, executive, language and academic function were used.

resultsIntelligence tests showed average results compared with norms. Five patients scored <-1 SD (70-84) and 3 low average (85-92) on full scale IQ. The patients scored average on subtests regarding executive function, except for significantly lower results in inhibition/switching (p = .004). In Rey complex figure test half of the patients scored below -1 SD. Language tests were normal except for significantly lower results in naming ability (p = .049) and in inference (p = .046). In academic tests, results were average, except for significantly lower results in reading speed (p = .024). Patients with learning difficulties performed worse in the tests.

conclusionsThe patients' functional outcome was favourable but, a not-negligible part of the patients displayed neurocognitive difficulties as revealed by extensive neuro-cognitive and academic testing. Thus, it is important to identify those in need of more thorough cognitive and pedagogic follow-up programmes, including school interventions.

Indexed as

AstrocytomaBrain NeoplasmsCognition DisordersChildCognitionHumansLanguageYoung Adultchildhoodcognitive outcomelanguage and learning difficultiespilocytic astrocytomaposterior fossa

Identifiers

PMID34231973
PMCPMC8955056
OpenAlexW3115817941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.