Evidence map›Paper›PMID 34231808›Full record

ArticleRevista Brasileira de terapia intensiva

Association of uteroglobin-related protein 1 with smoke inhalation injury severity.

Sabrina Frighetto Henrich, Tatiana Helena Rech, Cristiane Ritter, Monique Michels, Felipe Dal-Pizzol, Gilberto Friedman

Open access · diamondAbstract read
In one paragraph

Article in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Association of inhalation injury with ventilator-associated pneumonia and clinical outcomes in critically ill patients with burns: A retrospective study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sabrina Frighetto HenrichPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Tatiana Helena RechPrograma de Pós-Graduação em Ciências Médicas: Endocrinologia, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.ORCID http://orcid.org/0000-0001-9582-2821
Cristiane RitterPrograma de Pós-Graduação em Ciências Médicas, Universidade do Extremo Sul Catarinense - Criciúma (SC), Brasil.
Monique MichelsPrograma de Pós-Graduação em Ciências Médicas, Universidade do Extremo Sul Catarinense - Criciúma (SC), Brasil.ORCID http://orcid.org/0000-0001-8440-1976
Felipe Dal-PizzolPrograma de Pós-Graduação em Ciências Médicas, Universidade do Extremo Sul Catarinense - Criciúma (SC), Brasil.ORCID http://orcid.org/0000-0003-3003-8977
Gilberto FriedmanPrograma de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.ORCID http://orcid.org/0000-0001-9369-2488
Universidade Federal do Rio Grande do Sul · BRWeatherford College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate serum uteroglobin-related protein 1 expression early after smoke inhalation injuries and its association with the severity of inhalation injury in burned patients.

methodsSmoke or chemical inhalation injury is associated with morbidity and mortality. The consequences of inhalation result from an inflammatory response. Uteroglobin-related protein 1 is an anti-inflammatory protein and may improve lung inflammation. We hypothesized that uteroglobin-related protein 1 levels could reflect disease severity and predict outcome in patients with inhalation injury. Sixteen patients diagnosed with acute respiratory distress syndrome secondary to smoke inhalation injury were prospectively included in the study. Plasma was collected upon intensive care unit admission and within 24 hours of the inhalation injury. Bronchoscopies were carried out in all patients to assess the severity of inhalation injury within 72 hours. Uteroglobin-related protein 1 plasma levels were determined in duplicate with enzyme-linked immunosorbent assay.

resultsThe mean age was 23 ± 5 years, and the inhalation injury distribution was as follows: three of grade 1, four of grade 2, and nine of grade 3. The level of uteroglobin-related protein 1 was related to inhalation severity (grade 1: 0.389 ± 0.053 arbitrary units versus grade 2: 0.474 ± 0.0423 arbitrary units versus grade 3: 0.580 ± 0.094 arbitrary units; p = 0.007).

conclusionPlasma levels of uteroglobin-related protein 1 are associated with the degree of lung inhalation injury.

Indexed as

BurnsRespiratory Distress SyndromeSmoke Inhalation InjuryAdolescentAdultHumansIntensive Care UnitsUteroglobinYoung AdultUteroglobin

Identifiers

PMID34231808
PMCPMC8275074
OpenAlexW3179430260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.