Evidence map›Paper›PMID 34231530›Full record

ReviewCurrent opinion in ophthalmology2021

Applications of interpretability in deep learning models for ophthalmology.

Adam M Hanif, Sara Beqiri, Pearse A Keane, J Peter Campbell

Abstract readReview
In one paragraph

Review in Current opinion in ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Artificial intelligence in ophthalmology: opportunities, challenges, and ethical considerations.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. A Prediction Nomogram for Recurrent Retinal Detachment.Risk management and healthcare policy · 2023
    Article
  11. Deep learning for ultra-widefield imaging: a scoping review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam M HanifOphthalmology, Oregon Health & Science University, Portland, Oregon, USA.
Sara BeqiriUniversity College London Division of Medicine.
Pearse A KeaneMoorfields Eye Hospital NHS Foundation Trust.
J Peter CampbellOphthalmology, Oregon Health & Science University, Portland, Oregon, USA.

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Clinical and Genetic Analysis of Retinopathy of PrematurityR01EY019474 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2010 to 2020
$7.0M
Artificial Intelligence Assisted Panoramic Optical Coherence Tomography Angiography for Retinopathy of PrematurityR01HD107494 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell, Yifan Jian · 2021 to 2026
$2.4M
Clinical and genetic analysis of retinopathy of prematurityR01HD107493 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2021 to 2023
$1.8M
Robust AI to develop risk models in retinopathy of prematurity using deep learningR21EY031883 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, RUBIN, DANIEL L · 2020 to 2021
$472k
Artificial intelligence assisted panoramic Optical Coherence Tomography Angiography for Retinopathy of PrematurityR01EY031331 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER, JIAN, YIFAN · 2020 to 2020
$342k
Medical Research Council MR/T019050/1NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY019474NEI NIH HHS R01 EY031331NEI NIH HHS R21 EY031883NICHD NIH HHS R01 HD107493NICHD NIH HHS R01 HD107494
6 · The paper itself

Abstract

purpose of reviewIn this article, we introduce the concept of model interpretability, review its applications in deep learning models for clinical ophthalmology, and discuss its role in the integration of artificial intelligence in healthcare. RECENT

findingsThe advent of deep learning in medicine has introduced models with remarkable accuracy. However, the inherent complexity of these models undermines its users' ability to understand, debug and ultimately trust them in clinical practice. Novel methods are being increasingly explored to improve models' 'interpretability' and draw clearer associations between their outputs and features in the input dataset. In the field of ophthalmology, interpretability methods have enabled users to make informed adjustments, identify clinically relevant imaging patterns, and predict outcomes in deep learning models. SUMMARY: Interpretability methods support the transparency necessary to implement, operate and modify complex deep learning models. These benefits are becoming increasingly demonstrated in models for clinical ophthalmology. As quality standards for deep learning models used in healthcare continue to evolve, interpretability methods may prove influential in their path to regulatory approval and acceptance in clinical practice.

Indexed as

Deep LearningOphthalmologyArtificial IntelligenceClinical CompetenceComputer SimulationDiagnostic ImagingHumans

Identifiers

PMID34231530
PMCPMC8373813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.