ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2021
Systolic Blood Pressure Mediates Body Mass Index and Non-alcoholic Fatty Liver Disease: A Population-Based Study.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of SHBG as a Marker in Male Patients with Metabolic-Associated Fatty Liver Disease: Insights into Metabolic and Hormonal Status.Journal of clinical medicine · 2024Article
- Prevalence, characteristics, and risk factors of non-alcoholic fatty liver disease in North East of Iran: a population-based study.BMC gastroenterology · 2024Article
- Establishment of a risk score model for bladder urothelial carcinoma based on energy metabolism-related genes and their relationships with immune infiltration.FEBS open bio · 2023Article
- Relationship between lifestyle and metabolic factors and carotid atherosclerosis: A survey of 47,063 fatty and non-fatty liver patients in China.Frontiers in cardiovascular medicine · 2022Article
- Associations of lipid parameters with non-alcoholic fatty liver disease in type 2 diabetic patients according to obesity status and metabolic goal achievement.Frontiers in endocrinology · 2022Article
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6 authors.
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Abstract
backgroundBackground/Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Systolic blood pressure (SBP) and body mass index (BMI) are associated with NAFLD. We aimed to evaluate the mediating effect of SBP in the association between BMI and NAFLD.
methodsA total of 21 072 participants were enrolled. Multivariate logistic regression and linear regression models were used to describe the association between BMI, SBP, and NAFLD. The impact of SBP on the association between BMI and NAFLD was determined through mediation analysis.
resultsBMI was positively associated with incident NAFLD overall (odds ratio (OR) = 1.171, 95% CI (1.153-1.189)) and in the female (OR = 1.189, 95% CI (1.157-1.222)) and male groups (OR = 1.162, 95% CI (1.141-1.184)) (P < .001). SBP also showed positive effects in the general, female, and male groups (P < .001). The effect of BMI on SBP also indicated similar positive results in the general (β = 0.913, 95% CI (0.799-1.026)), female (β = 0.956, 95% CI (0.760-1.151)), and male (β = 0.867, 95% CI (0.727-1.006)) groups (P < .001). Mediation analysis showed that SBP contributed to 14.23% of the relationship between BMI and NAFLD in the general group and 31.07 and 22.67% of the relationship in the female and male groups of individuals younger than 50 years old, respectively. The mediation effect appeared higher among females than among males, especially in participants younger than 50 years.
conclusionSBP and BMI contribute to the development of NAFLD. SBP mediates a positive association between BMI and NAFLD among individuals younger than 50 years, especially among females.
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