ArticleeLife2021
Reduced synchroneity of intra-islet Ca
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- CHD4 and NKX2.2 Cooperate to Regulate β-Cell Function by Repressing Non-β-Cell Gene Programs.Diabetes · 2026Article
- Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes.Science translational medicine · 2026Article
- Stromal and Neuronal Sources of Slit2/3 Ligands in the Adult Pancreas Exhibit Distinct Expression Patterns Independent of Robo2 Receptor Expression in the Islet.bioRxiv : the preprint server for biology · 2026Article
- Stable intracranial imaging of dura mater-engrafted pancreatic islet cells in awake mice.Nature communications · 2025Article
- CHD4 and NKX2.2 Cooperate to Regulate Beta Cell Function by Repressing Non-Beta Cell Gene Programs.bioRxiv : the preprint server for biology · 2025Article
- Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication.Cell metabolism · 2025Article
- Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet CaeLife · 2025Article
- Intravital imaging reveals glucose-dependent cilia movement in pancreatic islets in vivo.Metabolism: clinical and experimental · 2025Article
- Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment.Science advances · 2025Article
- Glucokinase activity controls peripherally-located subpopulations of β-cells that lead islet CabioRxiv : the preprint server for biology · 2024Article
- Exploring pancreatic beta-cell subgroups and their connectivity.Nature metabolism · 2024Review
- Islet architecture in adult mice is actively maintained by Robo2 expression in β cells.Developmental biology · 2024Article
- Article
- Disrupted glucose homeostasis and glucagon and insulin secretion defects in Robo βKO mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Review
- Diverse roles for axon guidance pathways in adult tissue architecture and function.Natural sciences (Weinheim, Germany) · 2022Article
- Article
- Metabolic cycles and signals for insulin secretion.Cell metabolism · 2022Review
- Article
- Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Melissa T AdamsDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0001-5600-5562
JaeAnn M DwuletDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, United States.ORCID 0000-0003-2519-5193
Jennifer K BriggsDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, United States.
Christopher A ReissausHerman B Wells Center for Pediatric Research and Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, United States.
Erli JinDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, United States.
Joseph M SzulczewskiDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.
Melissa R LymanDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-0091-0413
Sophia M SdaoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, United States.
Vira KravetsDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, United States.ORCID 0000-0002-5147-309X
Sutichot D NimkulratDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.
Suzanne M PonikDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, United States.
Raghavendra G MirmiraKovler Diabetes Center and the Department of Medicine, University of Chicago, Chicago, United States.
Amelia K LinnemannHerman B Wells Center for Pediatric Research and Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, United States.
Richard Kp BenningerDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, United States.ORCID 0000-0002-5063-6096
Barak BlumDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, United States.ORCID 0000-0002-5308-4194
University of Wisconsin–Madison · USUniversity of Colorado Anschutz Medical Campus · USIndiana University School of MedicineUniversity of Chicago · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5MTranscriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5MValidation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5MEmergent Multi-Cellular Properties Regulating Pancreatic Islet FunctionR01DK106412 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Richard KP Benninger · 2015 to 2026
$4.0MRole of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and ReplicationR01DK124906 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2020 to 2026
$4.0MMulticellular Interactions and Dynamics of Pancreatic Islet Function in DiabetesR01DK102950 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BENNINGER, RICHARD KP · 2015 to 2024
$3.5MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4MNCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA216248NIA NIH HHS R01 AG062328NIDDK NIH HHS F31 DK126360NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK102950NIDDK NIH HHS R01 DK105588NIDDK NIH HHS R01 DK106412NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK121706NIDDK NIH HHS R01 DK124906NIDDK NIH HHS R01 DK127637NIDDK NIH HHS R56 DK106412NIGMS NIH HHS T32 GM007133NIH HHS S10 OD025040NIH HHS S10 OD025136
Abstract
The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes
Indexed as
AnimalsConnexinsGap Junction delta-2 ProteinGap JunctionsInsulin-Secreting CellsInsulin SecretionMiceMice, KnockoutNerve Tissue ProteinsReceptors, ImmunologicRoundabout ProteinsConnexinsGap Junction delta-2 ProteinNerve Tissue ProteinsReceptors, ImmunologicRobo2 protein, mouseRoundabout Proteinsbeta cellscell biologydevelopmental biologyintravital microscopyislet architectureislets of Langerhansmouserobo receptorssynchronous insulin secretion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.