ArticleTransboundary and emerging diseases2021
Emergence of porcine circovirus-like viruses associated with porcine diarrheal disease in China.
Article in Transboundary and emerging diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Emergence of a Novel CRESS-DNA Virus Associated with Swine Reproductive Failure in China.Transboundary and emerging diseases · 2026Article
- Identification and biochemical characterization of a novel porcine circovirus associated with porcine respiratory and diarrheal diseases.Microbiology spectrum · 2025Article
- The virome investigation of the globally endangered Eld's deer (Rucervus eldii) on Hainan Island, China.Scientific reports · 2025Article
- Massive expansion of the pig gut virome based on global metagenomic mining.NPJ biofilms and microbiomes · 2024Article
- DEAD-box RNA helicase 21 interacts with porcine circovirus type 2 Cap protein and facilitates viral replication.Frontiers in microbiology · 2024Article
- Genome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China.Virology journal · 2023Article
- Genetic characterization of four strains porcine circovirus-like viruses in pigs with diarrhea in Hunan Province of China.Frontiers in microbiology · 2023Article
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- First molecular detection and genetic analysis of porcine circovirus 4 in the Southwest of China during 2021-2022.Frontiers in microbiology · 2022Article
- Establishment of a Real-Time Quantitative PCR Assay for Porcine Circovirus-Like Virus and the First Evidence of Its Spread to Hainan and Jiangxi Provinces of China.Frontiers in veterinary science · 2022Article
- Article
- Emergence of porcine circovirus-like viruses associated with porcine diarrheal disease in China.Transboundary and emerging diseases · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus-like virus (Po-Circo-like [PCL] virus) is a CRESS DNA virus, the prevalence and pathogenicity of which are rarely studied.
methodsWe obtained two blood samples, four faecal samples, and two intestinal samples from a pig farm suffered from diarrheal disease in the delivery room in September 2020 and attempted to isolate and identify a causative pathogen. Subsequently, only PCL virus was positive, and qRT-PCR was designed to detect the loading titre of PCL virus. We then initiated a heightened surveillance program on the pathogenicity and epidemiology of PCL virus.
resultsSix PCL virus strains, with severe diarrhoea and haemorrhagic enteritis, have been found in six different pig farms in Guangdong province, China. A multiple sequence alignment of these PCL viruses and bovine circovirus-like virus/CH showed a similarity of 92.5-94.8% for the Rep protein, indicating these PCL viruses are highly homologous to Bo-Circo-like virus associated with calf diarrhoea. There were striking similarities between the PCL virus and bovine circovirus-like virus outbreaks in aetiological settings and Genomic sequence. We found that 11.2% (20/178) of diarrhoea samples and 13.3% (6/45) of pig farms were positive for PCL virus, suggesting that PCL virus may have spread widely in Pig farms. Moreover, this article underscores the risk of PCL virus spilling over and adapting to new species.
conclusionsPorcine circovirus-like virus was found to be associated with porcine diarrheal disease in China.
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