ArticleJournal of the American Geriatrics Society2021
Catechol-O-methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.Neurobiology of aging · 2025Article
- A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes.PloS one · 2025Article
- Article
- Pet Ownership and Maintenance of Physical Function in Older Adults-Evidence From the Baltimore Longitudinal Study of Aging (BLSA).Innovation in aging · 2023Article
- A training program for researchers in population neuroimaging: Early experiences.Frontiers in neuroimaging · 2022Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
importanceAdapting one's gait speed to external circumstances is critical for safe ambulation. Dopamine (DA), critical for adapting to increased task demands, predicts usual gait speed and may exert a greater role in complex tasks like rapid gait speed.
objectiveWe hypothesized that a genotypic proxy indicator of greater prefrontal DA signaling would predict significantly faster rapid gait.
designLongitudinal cohort study over 8 years.
settingCommunity-dwelling adults with no baseline mobility disability.
participantsN = 2353 participants from the Health ABC Study. MEASUREMENTS: Repeated measures of walking speed (meters/sec) were obtained in response to: "walk as fast as possible… (rapid gait) or "walk at your usual pace (usual gait)." Catechol-O-methyltransferase (COMT) val158met polymorphism indicated DA signaling (val/val = higher metabolism, lower DA signaling; met/met = lower metabolism, higher DA signaling).
resultsParticipants declined in rapid gait from 1.55 (SD = 0.33) to 1.35 m/s (SD = 0.34). Across the full follow-up period, the met/met genotype was associated with significantly greater rapid gait slowing. In mixed effect models, between-group differences were independent of covariates, and remained similar after adjustment for sensorimotor function, cognition, depressive symptoms, and energy. Follow-up analyses indicated the met/met genotype had a significantly faster rapid gait speed compared to the val/val genotype for the first 3 years (p < 0.01) but not years 4-8 (p > 0.05).
conclusionGreater prefrontal DA measured with COMT polymorphism may facilitate short-term adaptation to rapid walking demands that are lost over time. Studies should examine whether these effects are long-term and the underlying mechanistic pathways.
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