Evidence map›Paper›PMID 34231198›Full record

ReviewBritish journal of haematology2021

Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease.

Lydia H Pecker, Deva Sharma, Alecia Nero, Michael J Paidas, Russell E Ware, Andra H James, Kim Smith-Whitley

Open access · hybridAbstract readReview
In one paragraph

Review in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025
    Review
  5. Article
  6. Review
  7. Patient-reported pregnancy loss and maternal complications: Insights from the sickle cell disease implementation consortium.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  8. Love vs. Risk: Women with Sickle Cell Disease Face Reproductive Decision-Making Dilemmas.International journal of environmental research and public health · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 2 countries.

Lydia H PeckerDepartment of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8371-9752
Deva SharmaDivisions of Transfusion Medicine and Hematology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6437-5296
Alecia NeroDepartment of Medicine, Division of Hematology/Oncology, University of Texas Southwestern, Dallas, TX, USA.
Michael J PaidasDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Russell E WareDivision of Pediatric Hematology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Andra H JamesDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Department of Medicine, Division of Hematology, Duke University, Durham, UK.
Kim Smith-WhitleyDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USComputer Professionals for Social Responsibility · USDuke University · USJohns Hopkins University · USThe University of Texas Southwestern Medical Center · USUniversity of Miami · US

Funding

OVARIAN RESERVE IN POST-MENARCHAL FEMALES WITH SICKLE CELL ANEMIAK23HL146841 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PECKER, LYDIA · 2020 to 2024
$1.2M
NHLBI NIH HHS K23 HL146841
6 · The paper itself

Abstract

There is an immediate need to address long-standing questions about the reproductive health of girls and women with sickle cell disease (SCD). There are many SCD-related reproductive risks and uncertainties across girls' and women's reproductive life span, with particularly outstanding concerns about menstruation, contraception, fertility and pregnancy. Extant literature addressing women's reproductive health topics is mostly descriptive; there are few high-quality interventional studies. In 2020, the Centers for Disease Control and Prevention and the Foundation for Women and Girls with Blood Disorders convened an expert panel to assess the knowledge gaps in women's reproductive health in SCD. The panel identified significant limitations to clinical care due to the need for research. The panel also identified prominent barriers to research and care. In this report, we frame these issues, providing a roadmap for investigators, funding agencies, and policy makers to advance care for girls and women with SCD.

Indexed as

Anemia, Sickle CellReproductive HealthSexual HealthFemaleHealth Knowledge, Attitudes, PracticeHumansWomen's Healthhealth disparitiesreproductive healthsickle cell diseasewomen’s health

Identifiers

PMID34231198
PMCPMC8448913
OpenAlexW3178207427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.