ArticleEnvironmental science and pollution research international2021
Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Captive breeding of specialty animals represents an overlooked yet critical reservoir for spreading antibiotic resistance genes.The ISME journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
To comprehensively investigate the effects of exposure to legal doses of sulfamethoxazole (SMZ) in Nile tilapia (Oreochromis niloticus), fishes were exposed to diets supplemented with different doses of SMZ (NS, normal feed; LS, 20 mg/kg·day; MS, 200 mg/kg·day; and HS, 1000 mg/kg·day) for 4 weeks and then fed with normal feed for 4 weeks. General SMZ accumulation, growth performance, intestinal short-chain fatty acids, intestinal flora diversity, composition, and function were systemically evaluated. Results indicated that the SMZ accumulation in O. niloticus muscles, intestinal contents, and aquaculture environment positively correlated to the exposure dose. The growth performance, measured by weight increase, was MS>LS>NS, while HS antibiotics retarded the growth. SMZ-exposed O. niloticus had an increased number of fat particles in the liver and a change in the content of intestinal SCFAs. Moreover, SMZ exposure changed the biological diversity of the intestinal flora and subsequently induced microbiota dysbiosis, primarily inhibiting the growth of Fusobacteria, especially in HS group. Overall, exposure to higher SMZ doses than the recommended ones impair general intestinal functions and provokes health risk in fish. This study highlights the importance of rational and regulated use of SMZ in aquaculture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.