Evidence map›Paper›PMID 34231103›Full record

ArticleMolecular imaging and biology2021

Optimisation of the Synthesis and Cell Labelling Conditions for [

Ida Friberger, Emma Jussing, Jinming Han, Jeroen A C M Goos, Jonathan Siikanen, Helen Kaipe, Mélanie Lambert, Robert A Harris, Erik Samén, Mattias Carlsten and 2 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Evaluation of differentScientific reports · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ida FribergerDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Emma JussingDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Jinming HanDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jeroen A C M GoosDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jonathan SiikanenDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Helen KaipeDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Mélanie LambertDepartment of Medicine in Huddinge, Karolinska Institutet, Stockholm, Sweden.
Robert A HarrisDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Erik SaménDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Mattias CarlstenDepartment of Medicine in Huddinge, Karolinska Institutet, Stockholm, Sweden.
Staffan HolminDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Thuy A TranDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. thuy.tran@ki.se.ORCID http://orcid.org/0000-0003-0240-9988
Karolinska University Hospital · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a need to better characterise cell-based therapies in preclinical models to help facilitate their translation to humans. Long-term high-resolution tracking of the cells in vivo is often impossible due to unreliable methods. Radiolabelling of cells has the advantage of being able to reveal cellular kinetics in vivo over time. This study aimed to optimise the synthesis of the radiotracers [ PROCEDURES: Several parameters, such as buffers, pH, labelling time and temperature, were investigated to optimise the synthesis of [

resultsThe optimised synthesis of [

conclusionsOur study demonstrates that [

Indexed as

OxyquinolineRadioisotopesAnimalsCell Line, TumorDeferoxaminePositron-Emission TomographyRatsTissue DistributionZirconiumDeferoxamineOxyquinolineRadioisotopesZirconium89ZrCell labellingCell trackingDeferoxamineImagingOxinePET

Identifiers

PMID34231103
PMCPMC8578071
OpenAlexW3183016296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.