Evidence map›Paper›PMID 34231097›Full record

ArticleMolecular biology reports2021

Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.

G V Kakurina, O V Cheremisina, E E Sereda, E S Kolegova, I V Kondakova, E L Choinzonov

Abstract read
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In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

G V KakurinaTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050. kakurinagv@oncology.tomsk.ru.ORCID http://orcid.org/0000-0002-4506-9429
O V CheremisinaTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050.ORCID http://orcid.org/0000-0001-7234-4708
E E SeredaTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050.ORCID http://orcid.org/0000-0002-7752-9346
E S KolegovaTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050.ORCID http://orcid.org/0000-0001-9122-3274
I V KondakovaTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050.ORCID http://orcid.org/0000-0002-0947-8778
E L ChoinzonovTomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation, 634050.ORCID http://orcid.org/0000-0002-3651-0665
Russian Academy of Sciences · RU

Funding

Russian Foundation for Basic Research 20-015-00151
6 · The paper itself

Abstract

Actin-binding proteins (ABPs) and various signaling systems are involved in the process of squamous cell carcinoma of the larynx and hypopharynx (SCCLH) metastasis. The clinical significance of these proteins has not yet been determined. We analyzed the relationship between the mRNA levels of cofilin 1 (CFL1), profilin 1 (PFN1), adenylyl cyclase-associated protein 1 (CAP1), SNAI1 and RND3 and SCCLH metastasis. The serum levels of the above ABPs were estimated and the relationship between them and their mRNA expressions was analyzed. The expression levels of ABP mRNAs were measured by real-time RT-PCR in paired tissue samples taken from 54 patients with SCCLH (T1-4N0-1M0). Expression analysis was performed using the 2

Indexed as

AdultAgedCarcinoma, Squamous CellCell Cycle ProteinsCofilin 1Cytoskeletal ProteinsCytoskeletonFemaleHead and Neck NeoplasmsHumansHypopharyngeal NeoplasmsLaryngeal NeoplasmsMaleMicrofilament ProteinsMiddle AgedProfilinsCAP1 protein, humanCell Cycle ProteinsCFL1 protein, humanCofilin 1Cytoskeletal ProteinsMicrofilament ProteinsPFN1 protein, humanProfilinsrho GTP-Binding ProteinsRNA, MessengerRND3 protein, humanSNAI1 protein, humanSnail Family Transcription FactorsActin binding proteinsMetastasisRND3SNAI1Squamous cell carcinoma of the larynx and hypopharynx

Identifiers

PMID34231097
OpenAlexW3180947626

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.