Evidence map›Paper›PMID 34231090›Full record

ArticleBiotechnology letters2021

Biosensors for the detection of organophosphate exposure by a new diethyl thiophosphate-specific aptamer.

Napachanok Mongkoldhumrongkul Swainson, Pongsakorn Aiemderm, Chonnikarn Saikaew, Kanyanat Theeraraksakul, Pakjira Rimdusit, Charoenkwan Kraiya, Sasimanas Unajak, Kiattawee Choowongkomon

Abstract read
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In one paragraph

Article in Biotechnology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Napachanok Mongkoldhumrongkul SwainsonDepartment of Biochemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Bangkok, 10900, Chatuchak, Thailand.
Pongsakorn AiemdermDepartment of Biochemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Bangkok, 10900, Chatuchak, Thailand.
Chonnikarn SaikaewGenetic Engineering Interdisciplinary Program, Graduate School, Kasetsart University, 50 Ngam Wong Wan Rd, Bangkok, 10900, Chatuchak, Thailand.
Kanyanat TheeraraksakulGenetic Engineering Interdisciplinary Program, Graduate School, Kasetsart University, 50 Ngam Wong Wan Rd, Bangkok, 10900, Chatuchak, Thailand.
Pakjira RimdusitOffice of Disease Prevention and Control 4, Department of Disease Control, Saraburi, 18120, Thailand.
Charoenkwan KraiyaElectrochemistry and Optical Spectroscopy Center of Excellence, Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand.
Sasimanas UnajakDepartment of Biochemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Bangkok, 10900, Chatuchak, Thailand.
Kiattawee ChoowongkomonDepartment of Biochemistry, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Bangkok, 10900, Chatuchak, Thailand. fsciktc@ku.ac.th.ORCID http://orcid.org/0000-0002-2421-7859
Kasetsart University · THChulalongkorn University · THDepartment of Disease Control · TH

Funding

Kasetsart University the Omics Center for Agriculture, Bioresources, Food and Health, Kasetsart UniversityKasetsart University Research and Development Institute KURDI (FF(KU)6.64)
6 · The paper itself

Abstract

objectiveAn aptamer specifically binding to diethyl thiophosphate (DETP) was constructed and incorporated in an optical sensor and electrochemical techniques to enable the specific measurement of DETP as a metabolite and a biomarker of organophosphate exposure.

resultsA DETP-bound aptamer was selected from the library using capillary electrophoresis-systematic evolution of ligands by exponential enrichment (CE-SELEX). A colorimetric method revealed that the aptamer had the highest affinity for DETP, with a mean K

conclusionsThe current method showed great promise in using the DETP-specific aptamer to detect the exposure history to organophosphates by measuring their metabolites, although degradation of organophosphate parent compounds might occur.

Indexed as

Aptamers, NucleotideBiosensing TechniquesCalorimetryElectrochemical TechniquesHumansMolecular Docking SimulationOrganophosphatesPhosphatesSELEX Aptamer TechniqueSensitivity and SpecificityAptamers, NucleotideOrganophosphatesPhosphatesthiophosphoric acidAptasensorCapillary electrophoresisCyclic voltammetryDiethyl thiophosphateElectrochemical impedance spectroscopyOrganophosphate metabolites

Identifiers

PMID34231090
OpenAlexW3133917176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.