Evidence map›Paper›PMID 34231037›Full record

ArticleEuropean radiology2022

Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: comparison with morphological MRCP, MR elastography, and biochemical risk scores.

Marwa F Ismail, Gideon M Hirschfield, Bettina Hansen, Monica Tafur, Khaled Y Elbanna, Marc H Goldfinger, Gerard R Ridgway, Kartik S Jhaveri

Abstract read
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In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marwa F IsmailToronto Centre for Liver Disease, University Health Network, University of Toronto, Institute of Health Policy Management and Evaluation, Toronto, ON, Canada.
Gideon M HirschfieldToronto Centre for Liver Disease, University Health Network, Mt. Sinai & WCH, University of Toronto, Institute of Health Policy Management and Evaluation, Toronto, ON, Canada.
Bettina HansenToronto Centre for Liver Disease, University Health Network, University of Toronto, Institute of Health Policy Management and Evaluation, Toronto, ON, Canada.
Monica TafurJoint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada.
Khaled Y ElbannaJoint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada.
Marc H GoldfingerPerspectum Ltd, Oxford, UK.
Gerard R RidgwayPerspectum Ltd, Oxford, UK.
Kartik S JhaveriJoint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada. Kartik.Jhaveri@uhn.ca.ORCID http://orcid.org/0000-0003-0938-0321
University Health Network · CASt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the association of MRCP+ parameters with biochemical scoring systems and MR elastography (MRE) in primary sclerosing cholangitis (PSC). To evaluate the incremental value of combining MRCP+ with morphological scores in associating with biochemical scores. METHODS AND MATERIALS: MRI images, liver stiffness measurements by MRE, and biochemical testing of 65 patients with PSC that were retrospectively enrolled between January 2014 and December 2015 were obtained. MRCP+ was used to post-process MRCP images to obtain quantitative measurements of the bile ducts and biliary tree. Linear regression analysis was used to test the associations. Bootstrapping was used as a validation method.

resultsThe total number of segmental strictures had the strongest association with Mayo Risk Score (R

conclusionsMRCP+ demonstrated a significant association with biochemical scores and MRE. The association of MRCP+ with the biochemical scores was generally comparable to ANALI scores. MRCP+ enhanced the association of ANALI2 and MRE with the Mayo Risk Score. KEY POINTS: • MRCP+ has the potential to act as a risk stratfier in PSC. • MRE outperformed MRCP+ for risk stratifcation. • Combination of MRCP+ with MRE and ANALI scores improved overall performace as risk stratifiers.

Indexed as

Cholangitis, SclerosingElasticity Imaging TechniquesCholangiopancreatography, Magnetic ResonanceHumansMagnetic Resonance ImagingRetrospective StudiesRisk AssessmentRisk FactorsCirrhosisElastographyLiverMagnetic resonance cholangiopancreatographyStrictures

Identifiers

PMID34231037
OpenAlexW3179001082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.