ArticlePlant cell reports2021
Function identification of miR394 in tomato resistance to Phytophthora infestans.
Article in Plant cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Exploring the CeRNA landscape in plants: advances, methods, and challenges.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Auxin-induced AsARF16 complex orchestrates lncRNA125175-mediated ceRNA networks to regulate garlic somatic embryogenesis.Horticulture research · 2026Article
- Dual impact of ambient pH on the virulence of Phytophthora nicotianae and resistance in tobacco.Plant cell reports · 2026Article
- Integrated expression analysis to elucidate the role of miR394 during flowering in Arabidopsis thaliana.Plant cell reports · 2025Article
- Review
- Characterization of PAMP-induced peptides and mechanistic insights into SlPIP2-mediated defense in tomato.Plant cell reports · 2025Article
- An efficient CRISPR-Cas12a-mediated MicroRNA knockout strategy in plants.Plant biotechnology journal · 2025Article
- Underground communication: Long non-coding RNA signaling in the plant rhizosphere.Plant communications · 2024Review
- Article
- The lncRNA20718-miR6022-RLPs module regulates tomato resistance to Phytophthora infestans.Plant cell reports · 2024Article
- microRNAs: Key Regulators in Plant Responses to Abiotic and Biotic Stresses via Endogenous and Cross-Kingdom Mechanisms.International journal of molecular sciences · 2024Review
- Plant microRNAs regulate the defense response against pathogens.Frontiers in microbiology · 2024Review
- Rose long noncoding RNA lncWD83 promotes flowering by modulating ubiquitination of the floral repressor RcMYC2L.Plant physiology · 2023Article
- Research Progress ofJournal of fungi (Basel, Switzerland) · 2023Review
- Tae-miR397 Negatively Regulates Wheat Resistance toPlants (Basel, Switzerland) · 2023Article
- The effectors of Phytophthora infestans impact host immunity upon regulation of antagonistic hormonal activities.Planta · 2023Article
- Article
- Roles of long non-coding RNAs in plant immunity.PLoS pathogens · 2023Review
- Wheat Long Noncoding RNAs from Organelle and Nuclear Genomes Carry Conserved microRNA Precursors Which May Together Comprise Intricate Networks in Insect Responses.International journal of molecular sciences · 2023Article
- Identification of miRNAs Involving Potato-Plants (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
key messageMiR394 plays a negative role in tomato resistance to late blight. The lncRNA40787 severing as an eTM for miR394 to regulate LCR and exerting functions in tomato resistance. Tomato (Solanum lycopersicum), which was used as model species for studying the mechanism of plant disease defense, is susceptible to multiple pathogens. Non-coding RNA (ncRNA) has a pivotal role in plants response to biological stresses. It has previously been observed that the expression level of miR394 changed significantly after the infection of various pathogens. However, there has been no detailed investigation of the accumulated or suppressed mechanism of miR394. Our previous study predicted three lncRNAs (lncRNA40787, lncRNA27177, and lncRNA42566) that contain miR394 endogenous target mimics (eTM), which may exist as the competitive endogenous RNAs (ceRNAs) of miR394. In our study, the transcription levels of these three lncRNAs were strongly up-regulated in tomato upon infection with P. infestans. In contrast with the three lncRNAs, the accumulation of miR394 was significantly suppressed. Based on the expression pattern, and value of minimum free energy (mfes) that represents the binding ability between lncRNA and miRNA, lncRNA40787 was chosen for further investigation. Results showed that overexpression of lncRNA40787 reduced the expression of miR394 along with decreased lesion area and enhanced disease resistance. Overexpression of miR394, however, decreased the expression of its target gene Leaf Curling Responsiveness (LCR), and suppressed the synthesis components genes of jasmonic acid (JA), depressing the resistance of tomato to P. infestans infection. Taken together, our findings indicated that miR394 can be decoyed by lncRNA40787, and negatively regulated the expression of LCR to enhance tomato susceptibility under P. infestans infection. Our study provided detailed information on the lncRNA40787-miR394-LCR regulatory network and serves as a reference for future research.
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