ArticleAfrican journal of urology : the official journal of the Pan African Urological Surgeons' Association (PAUSA)2021
Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways.
Article in African journal of urology : the official journal of the Pan African Urological Surgeons' Association (PAUSA), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Electrophysiological and Molecular Features of Remdesivir-Induced Cardiac Toxicity in Male and Female Guinea Pigs.International journal of molecular sciences · 2026Article
- SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023Review
- Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID Orchitis in Brothers.Urology · 2022Article
- Cardiovascular Risk Factors and Clinical Outcomes among Patients Hospitalized with COVID-19: Findings from the World Heart Federation COVID-19 Study.Global heart · 2022Article
- NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems.Journal of reproductive immunology · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurs through binding and internalization of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell membrane. Pathological changes are caused by damage and failure of vital organs that express high levels of ACE2, including the lungs, the heart and the kidneys. The aim of this study was to investigate ACE2 gene expression in the human male urogenital tract using a public database.
methodsA search of transcriptomic datasets from a database to investigate ACE2 gene expression in human urogenital tract tissue.
resultsThe gene expression profile demonstrated that ACE2 gene expression was higher in human kidney cortex and testis than human lung tissue. The gene expression profile demonstrated that ACE2 gene expression in the human bladder and prostate was comparable to human lung tissue.
conclusionsMale urogenital tissues are directly susceptible to SARS-CoV-2 infection through the expression of ACE2. Moreover, the SARS-Cov-2/ACE2 interaction may disturb the male genital and reproductive functions.
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