Evidence map›Paper›PMID 34230628›Full record

ArticleEuropean journal of clinical nutrition2022

A Mediterranean diet microsimulation modeling in relation to cardiovascular disease burden: the ATTICA and GREECS epidemiological studies.

Matina Kouvari, Thomas Tsiampalis, Christina Chrysohoou, Ekavi Georgousopoulou, Venetia Notara, Kyriakos Souliotis, Theodora Psaltopoulou, Mary Yannakoulia, Christos Pitsavos, Demosthenes B Panagiotakos

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Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Matina KouvariDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Thomas TsiampalisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Christina ChrysohoouFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Ekavi GeorgousopoulouDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Venetia NotaraDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Kyriakos SouliotisFaculty of Social Sciences, University of Peloponnese, Korinthos, Greece.
Theodora PsaltopoulouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Athens, Greece.
Mary YannakouliaDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Christos PitsavosFirst Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Demosthenes B PanagiotakosDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. dbpanag@hua.gr.ORCID http://orcid.org/0000-0001-8583-153X
Harokopio University of Athens · GRNational and Kapodistrian University of Athens · GRUniversity of Canberra · AUAustralian National University · AUUniversity of Peloponnese · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo quantify the changes in 10-year cardiovascular disease (CVD) onset, recurrence, and mortality, in relation to transitioning from low to a higher level of adherence to the Mediterranean diet. SUBJECTS/

methodsAn individual-level microsimulation was created based on ATTICA (2002-2012, n = 3042 subjects free-of-CVD) and GREECS (2004-2014, n = 2172 patients with acute coronary syndrome (ACS)) studies (in total n = 5214). Eight scenarios regarding the proportion of participants and the size of improvement of the level of adherence to the Mediterranean diet (corresponding to one to ten point increases in MedDietScore) were compared in terms of relative change in CVD incidence and mortality, as well as, the number of preventable CVD events and deaths.

resultsImproving adherence to the Mediterranean diet in at least 10% of the population, a significant relative percentage reduction could be observed in 10-year CVD onset, recurrence, and mortality. At least 851 first CVD events, 374 recurrent CVD events, and 205 CVD deaths per 100,000 of the population could be averted or delayed. In addition, Mediterranean diet clustering revealed that scoring higher in fruits, vegetables, whole wheat products, and legumes was more important than achieving higher scores in low consumption of meat and full-fat dairy products against CVD (all HRs in the former cluster were lower than the latter, indicating a stronger protective effect).

conclusionsThis microsimulation process confirms the added value of the Mediterranean diet in primary and secondary CVD prevention having great achievements even with modifications in a small part of the population (10%), while challenges the orientation of Mediterranean-diet interventions giving higher weights to plant-based part.

Indexed as

Cardiovascular DiseasesDiet, MediterraneanEpidemiologic StudiesHumansIncidenceMorbidityRisk Factors

Identifiers

PMID34230628
OpenAlexW3180265272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.