ArticleSpinal cord2021
Are early clinical manifestations of spasticity associated with long-term functional outcome following spinal cord injury? A retrospective study.
Article in Spinal cord, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06564714 (Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury to Promote Long-term Neurofunctional Recovery), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury to Promote Long-term Neurofunctional Recovery: a Randomized Clinical Trial
Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of early acute in-bed leg cycling initiated from the intensive care unit following severe traumatic spinal cord injury: final results from the PROMPT-SCI trial.Critical care (London, England) · 2026Trial
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of spasticity on quality of life of Lebanese individuals with spinal cord injury: Validity and reliability of the Arabic modified patient-reported impact of spasticity measure.The journal of spinal cord medicine · 2025Article
- Early functional proprioceptive stimulation in high spinal cord injury: a pilot study.Frontiers in rehabilitation sciences · 2025Article
- Combined Extracorporeal Shock Wave Therapy and Botulinum Toxin Injection for Spasticity in the Acute Phase of Spinal Cord Injury: A Case Report.Progress in rehabilitation medicine · 2025Article
- Significance of physical factors on activities of daily living in patients with tetraplegia after spinal cord injury: a retrospective study.BMC sports science, medicine & rehabilitation · 2024Article
- Are early-onset spasms predictive of poor neurological recovery after traumatic spinal cord injury?The journal of spinal cord medicine · 2024Article
- Spasticity Predicts Motor Recovery for Patients with Subacute Motor Complete Spinal Cord Injury.Annals of neurology · 2023Article
- Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.International journal of molecular sciences · 2022Article
- Effects of cortical intermittent theta burst stimulation combined with precise root stimulation on motor function after spinal cord injury: a case series study.Neural regeneration research · 2022Article
- Evidence of treating spasticity before it develops: a systematic review of spasticity outcomes in acute spinal cord injury interventional trials.Therapeutic advances in neurological disorders · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
designRetrospective study of a prospective cohort of patients with traumatic spinal cord injury (SCI).
objectivesDetermine the relationship between the occurrence of early spasticity, defined as the development of signs and/or symptoms of spasticity during the hospitalization in traumatology, and the functional outcome 6-12 months following a SCI. Secondly, to determine the specific impact of early clonus, velocity-dependent hypertonia and/or muscle spasms on the functional outcome at the same timepoint.
settingSingle trauma center specialized in SCI care.
methodsOne hundred sixty-two patients sustaining an acute traumatic SCI were included in the analyses. Comparative analysis was performed to describe the characteristics of patients with early spasticity. Correlations were performed to determine the relationship between the clinical signs of spasticity and the Spinal Cord Independence Measure (SCIM) scores collected 6-12 months after SCI.
results51.9% of the cohort developed clinical signs of spasticity during the hospitalization in traumatology (29.7 days) following SCI. These showed a significantly lower total SCIM score and subscores compared to individuals without early spasticity at follow-up (p < 0.05). After adjusting for confounding factors, the occurrence of early spasms was only clinical sign of spasticity significantly associated with a decreased mobility at follow-up (r = -0.17, p = 0.04).
conclusionsThe development of signs and symptoms of spasticity, in particular the occurrence of spasms in the first month following the injury may be associated with decreased functional outcome and mobility. Early assessment of spasticity following SCI is thus recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.