ArticleNature communications2021
Lactate sensing mechanisms in arterial chemoreceptor cells.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Changes in miRNA expression in patients with peripheral arterial vascular disease during moderate- and vigorous-intensity physical activity.European journal of applied physiology · 2023Trial
- The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.Brain, behavior, & immunity - health · 2026Review
- Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Retrospective Cohort Analysis of TyG, TyG-SI, and TyG-Lac Indices as Predictors of 360-Day Mortality in Critically Ill Ischemic Stroke Patients.Journal of clinical medicine · 2026Article
- Heart rate thresholds as integrative biomarkers: a systems approach to exercise physiology and cardiovascular regulation.European journal of applied physiology · 2025Review
- Genetic map of the carotid body stem cell niche with focus on the OScientific reports · 2025Article
- The Role of Lactylation in Virus-Host Interactions.International journal of molecular sciences · 2025Review
- The value of blood lactate and lactate clearance rate in evaluating the prognosis of athletes with heat illness of varying degrees after high-intensity exercise.BMC sports science, medicine & rehabilitation · 2025Article
- The polymorphism T1470A of the SLC16A1 gene is associated with the lactate and ventilatory thresholds but not with fat oxidation capacity in young men.European journal of applied physiology · 2024Article
- Blood oxygen regulation via P2Y12R expressed in the carotid body.Respiratory research · 2024Article
- Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance.Frontiers in physiology · 2024Review
- Carotid Body Function in Tyrosine Hydroxylase Conditional Olfr78 Knockout Mice.Function (Oxford, England) · 2024Article
- Observational
- Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review.Nutrients · 2023Review
- Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases.European journal of heart failure · 2023Review
- Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice.Nature communications · 2023Article
- Constitutive Expression of Hif2α Confers Acute OAdvances in experimental medicine and biology · 2023Article
- Acute oxygen sensing by vascular smooth muscle cells.Frontiers in physiology · 2023Review
- The Carotid Body "Tripartite Synapse": Role of Gliotransmission.Advances in experimental medicine and biology · 2023Review
- Mechanisms of Chemosensory Transduction in the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing medical relevance. Lactate levels in the blood can increase in both normal and pathophysiological conditions (e.g., hypoxia, physical exercise, or sepsis), however the manner by which these changes are sensed and induce adaptive responses is unknown. Here we show that the carotid body (CB) is essential for lactate homeostasis and that CB glomus cells, the main oxygen sensing arterial chemoreceptors, are also lactate sensors. Lactate is transported into glomus cells, leading to a rapid increase in the cytosolic NADH/NAD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.