ArticleNature communications2021
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration.Current biology : CB · 2025Article
- Wiring of a low-dimensional integrator network.Nature neuroscience · 2024Article
- Predicting modular functions and neural coding of behavior from a synaptic wiring diagram.Nature neuroscience · 2024Article
- Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish.Current biology : CB · 2024Article
- Dimensionality reduction reveals separate translation and rotation populations in the zebrafish hindbrain.Current biology : CB · 2023Article
- Saccade-Responsive Visual Cortical Neurons Do Not Exhibit Distinct Visual Response Properties.eNeuro · 2023Article
- Article
- Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades.Nature communications · 2021Article
- A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Organisms have the capacity to make decisions based solely on internal drives. However, it is unclear how neural circuits form decisions in the absence of sensory stimuli. Here we provide a comprehensive map of the activity patterns underlying the generation of saccades made in the absence of visual stimuli. We perform calcium imaging in the larval zebrafish to discover a range of responses surrounding spontaneous saccades, from cells that display tonic discharge only during fixations to neurons whose activity rises in advance of saccades by multiple seconds. When we lesion cells in these populations we find that ablation of neurons with pre-saccadic rise delays saccade initiation. We analyze spontaneous saccade initiation using a ramp-to-threshold model and are able to predict the times of upcoming saccades using pre-saccadic activity. These findings suggest that ramping of neuronal activity to a bound is a critical component of self-initiated saccadic movements.
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