Evidence map›Paper›PMID 34230216›Full record

ArticleGut2022

Lochlan Fennell, Alexandra Kane, Cheng Liu, Diane McKeone, Gunter Hartel, Chang Su, Catherine Bond, Mark Bettington, Barbara Leggett, Vicki Whitehall

Open access · hybridAbstract read
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. BRAFiScience · 2025
    Article
  6. BRAFiScience · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lochlan FennellThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia Lochlan.Fennell@qimrberghofer.edu.au.ORCID 0000-0003-3214-3527
Alexandra KaneThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Cheng LiuThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Diane McKeoneThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Gunter HartelStatistics Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Chang SuThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Catherine BondThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Mark BettingtonEnvoi Specialist Pathologists, Brisbane, Queensland, Australia.
Barbara LeggettThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Vicki WhitehallThe Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
The University of Queensland · AUQIMR Berghofer Medical Research Institute · AUQueensland Health · AUEnvoi Specialist Pathologists · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSessile serrated lesions (SSLs) are common across the age spectrum, but the

designWe used an inducible model of

resultsInducing

conclusionsSSLs arising in the aged intestine are at a significantly higher risk of spontaneous neoplastic progression. These findings provide support for a new conceptual model for serrated colorectal carcinogenesis, whereby risk of

Indexed as

Colonic PolypsColorectal NeoplasmsAgedAnimalsCell Transformation, NeoplasticDNA MethylationHumansIntestinal MucosaMiceMutationProto-Oncogene Proteins B-rafBRAF protein, humanProto-Oncogene Proteins B-rafadenocarcinomaageingcolonic polypscolorectal neoplasiaoncogenes

Identifiers

PMID34230216
PMCPMC9120393
OpenAlexW3183105189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.