Evidence map›Paper›PMID 34230209›Full record

ArticleScience signaling2021

Long-chain polyphosphates impair SARS-CoV-2 infection and replication.

Veronica Ferrucci, Dae-Young Kong, Fatemeh Asadzadeh, Laura Marrone, Angelo Boccia, Roberto Siciliano, Giuseppina Criscuolo, Camilla Anastasio, Fabrizio Quarantelli, Marika Comegna and 25 more

Open access · hybridAbstract read
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

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  17. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  18. Article
  19. Review
  20. SARS-CoV-2 Subgenomic N (Diagnostics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 9 institutions in 2 countries.

Veronica FerrucciCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0002-2019-6501
Dae-Young KongGinxen Co., Ltd., 2F, Daewoong Building, Seocho-gu, Seoul, South Korea.ORCID 0000-0002-6480-5364
Fatemeh AsadzadehCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Laura MarroneCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Angelo BocciaDipartimento di Medicina Molecolare e Biotecnologie Mediche (DMMBM), "Federico II" University of Naples, Naples 80131, Italy.
Roberto SicilianoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Giuseppina CriscuoloCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Camilla AnastasioCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Fabrizio QuarantelliCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0003-0744-5734
Marika ComegnaCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Ida PisanoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Margherita PassarielloCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0003-0994-4684
Ilaria IacobucciCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0001-6210-5607
Rosa Della MonicaCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Barbara IzzoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Pellegrino CerinoIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.
Giovanna FuscoIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.ORCID 0000-0003-3139-7672
Maurizio ViscardiIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.ORCID 0000-0003-1813-5993
Sergio BrandiIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.ORCID 0000-0001-8345-7564
Bianca Maria PierriIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.ORCID 0000-0001-5248-3014
Giorgia BorrielloIstituto Zooprofilattico Sperimentale del Mezzogiorno, Naples 80055, Italy.ORCID 0000-0002-4672-6793
Claudia TiberioU.O.C. di Patologia Clinica Ospedale D. Cotugno, Azienda Sanitaria Ospedali dei Colli, Naples 80131, Italy.
Luigi AtripaldiU.O.C. di Patologia Clinica Ospedale D. Cotugno, Azienda Sanitaria Ospedali dei Colli, Naples 80131, Italy.ORCID 0000-0002-8380-5175
Martina BianchiSapienza Università di Roma, Department of Biochemical Sciences "A. Rossi Fanelli", Rome 00185, Italy.ORCID 0000-0002-2547-5999
Giovanni PaolellaCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0002-1836-5281
Ettore CapoluongoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Giuseppe CastaldoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0002-4036-0874
Lorenzo ChiariottiCEINGE Biotecnologie Avanzate, Naples 80145, Italy.
Maria MontiCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0002-7775-7154
Claudia De LorenzoCEINGE Biotecnologie Avanzate, Naples 80145, Italy.ORCID 0000-0002-6195-5631
Kyong-Seop YunHaimBio Co. Ltd, Industrial Park, Korea University, Seongbuk-gu, Seoul, South Korea.ORCID 0000-0002-1324-8908
Stefano PascarellaSapienza Università di Roma, Department of Biochemical Sciences "A. Rossi Fanelli", Rome 00185, Italy.ORCID 0000-0002-6822-4022
Jae-Ho CheongDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea. jhcheong@yuhs.ac hykim@haimbio.com massimo.zollo@unina.it.ORCID 0000-0002-1703-1781
Hong-Yeoul KimGinxen Co., Ltd., 2F, Daewoong Building, Seocho-gu, Seoul, South Korea. jhcheong@yuhs.ac hykim@haimbio.com massimo.zollo@unina.it.ORCID 0000-0003-3018-0316
Massimo ZolloCEINGE Biotecnologie Avanzate, Naples 80145, Italy. jhcheong@yuhs.ac hykim@haimbio.com massimo.zollo@unina.it.ORCID 0000-0002-0970-7243
Ceinge Biotecnologie Avanzate (Italy) · ITIstituto Zooprofilattico Sperimentale del Mezzogiorno · ITFederico II University Hospital · ITKorea University · KROspedale D. Cotugno · ITSapienza University of Rome · ITDaewoo Electronics (South Korea) · KRUniversity of Naples Federico II · ITYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic polyphosphates (polyPs) are linear polymers composed of repeated phosphate (PO

Indexed as

COVID-19 Drug TreatmentAdministration, InhalationAmino Acid SequenceAngiotensin-Converting Enzyme 2AnimalsAntiviral AgentsCaco-2 CellsChlorocebus aethiopsCoronavirus RNA-Dependent RNA PolymeraseCOVID-19CytokinesHEK293 CellsHost Microbial InteractionsHumansIn Vitro TechniquesModels, BiologicalACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus RNA-Dependent RNA PolymeraseCytokinesNSP12 protein, SARS-CoV-2PolyphosphatesProteasome Endopeptidase ComplexRNA, Viral

Identifiers

PMID34230209
PMCPMC8432949
OpenAlexW3178282193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.