Evidence map›Paper›PMID 34229835›Full record

ReviewClinics in liver disease2021

Epidemiology of Alcohol-Associated Liver Disease.

Sen Han, Zhihong Yang, Ting Zhang, Jing Ma, Kristina Chandler, Suthat Liangpunsakul

Abstract readReview
In one paragraph

Review in Clinics in liver disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Significant Liver Disease Among Increased Alcohol Consumers More Than Doubled From 1999 to 2020 Alongside Evolving US Population Demographics.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Article
  4. Latent TB treatment outcomes in patients with chronic liver disease: A retrospective cohort study.Journal of clinical tuberculosis and other mycobacterial diseases · 2025
    Article
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Article
  10. Novel medications for problematic alcohol use.The Journal of clinical investigation · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Telomere length in patients with alcohol-associated liver disease: a brief report.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022
    Article
  16. Review
  17. Article
  18. Seabuckthorn polysaccharide combined withFrontiers in endocrinology · 2022
    Article
  19. Review
  20. Epidemiology and Disease Burden of Alcohol Associated Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sen HanDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA; Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing, China.
Zhihong YangDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA.
Ting ZhangDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA.
Jing MaDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA.
Kristina ChandlerDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA. Electronic address: sliangpu@iu.edu.

Funding

Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Indiana University Data Coordinating CenterU24AA026969 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI SAMER GAWRIEH, WANZHU TU · 2018 to 2026
$20.2M
Novel biomarkers as a clinical tool for excessive alcohol use screeningR01AA025208 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, TU, WANZHU · 2016 to 2020
$1.7M
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver diseaseR01DK107682 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE, LIANGPUNSAKUL, SUTHAT · 2016 to 2019
$1.4M
Immunological Profiles and prognostic outcomes in patients with alcoholic hepatitisU01AA026917 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2018 to 2022
$1.2M
Novel animal models to study miRNA-mediated alcoholic liver diseaseUH3AA026903 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2020 to 2022
$1.2M
Integrating LncRNA to Methionine Metabolism in Alcoholic Fatty LiverK01AA026385 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI YANG, ZHIHONG · 2018 to 2022
$807k
Novel animal models to study miRNA-mediated alcoholic liver diseaseUH2AA026903 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2018 to 2019
$447k
Serum Proteomic Profiles as Biomarkers of Abusive Alcohol ConsumptionI01CX000361 · VA · RLR VA MEDICAL CENTER · PI LIANGPUNSAKUL, SUTHAT · 2012 to 2025
–
CSRD VA I01 CX000361NIAAA NIH HHS K01 AA026385NIAAA NIH HHS R01 AA025208NIAAA NIH HHS U01 AA026917NIAAA NIH HHS U24 AA026969NIAAA NIH HHS UH2 AA026903NIAAA NIH HHS UH3 AA026903NIDDK NIH HHS R01 DK107682
6 · The paper itself

Abstract

Alcohol-associated liver disease (ALD) is a consequence of excessive alcohol use. It comprises a spectrum of histopathologic changes ranging from simple steatosis, steatohepatitis, and cirrhosis to hepatocellular carcinoma. The public health impact of ALD is growing because of an increase in the prevalence and incidence of ALD in parallel with liver transplant and mortalities. There are multiple factors involved in the pathogenesis and progression of ALD. Reducing alcohol consumption is the cornerstone of ALD management. The efforts to reduce excessive alcohol use at the individual and population levels are urgently needed to prevent adverse outcomes from ALD.

Indexed as

Carcinoma, HepatocellularLiver Diseases, AlcoholicLiver NeoplasmsLiver TransplantationHumansLiver CirrhosisAlcoholicEpidemiologyLiver diseasesPublic health

Identifiers

PMID34229835
PMCPMC8996817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.