Evidence map›Paper›PMID 34229714›Full record

ArticleJournal of translational medicine2021

Chronic obstructive pulmonary disease does not impair responses to resistance training.

Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02598830 (The Granheim COPD Study), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02598830 nacompletednot on this map

The Granheim COPD Study: Effects of Vitamin D3-supplementation on the Efficacy of Strength Training in COPD Patients and Healthy Controls - a Double-blinded RCT

TypeinterventionalSponsorInland Norway University of Applied SciencesRan2015 to 2018Enrolled97ConditionsChronic Obstructive Pulmonary DiseaseArmsVitamin D3, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Pulmonary rehabilitation and physical interventions.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Knut Sindre MølmenSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway. knut.sindre.molmen@inn.no.ORCID 0000-0001-8924-6848
Daniel HammarströmSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway.
Gunnar Slettaløkken FalchSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway.
Morten GrundtvigDepartment of Medicine, Innlandet Hospital Trust, Lillehammer, Norway.
Lise KollDepartment of Pathology, Innlandet Hospital Trust, Lillehammer, Norway.
Marita HanestadhaugenDepartment of Pathology, Innlandet Hospital Trust, Lillehammer, Norway.
Yusuf KhanSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway.
Rafi AhmadDepartment of Biotechnology, Inland Norway University of Applied Sciences, Hamar, Norway.
Bente MalerbakkenLillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway.
Tore Jørgen RødølenInnlandet Hospital Trust, Granheim Lung Hospital, Follebu, Norway.
Roger LienInnlandet Hospital Trust, Granheim Lung Hospital, Follebu, Norway.
Bent R RønnestadSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway.
Truls RaastadDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Stian EllefsenSection for Health and Exercise Physiology, Inland Norway University of Applied Sciences, P.O. Box 422, 2604, Lillehammer, Norway.
Innlandet Hospital Trust · NOUniversity of Inland Norway · NONorwegian School of Sport Sciences · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach.

methodsSubjects with COPD (n = 20, GOLD II-III, FEV

resultsCOPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein]

conclusionsCOPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies.

trial registrationClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830.

Indexed as

Pulmonary Disease, Chronic ObstructiveResistance TrainingAgedCross-Sectional StudiesExercise ToleranceHumansMiddle AgedMuscle, SkeletalMuscle StrengthAnabolic resistanceCOPDPathophysiologySkeletal muscleStrength trainingTraining load

Identifiers

PMID34229714
PMCPMC8261934
OpenAlexW3182903281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.