ArticleBMC public health2021
Trends in cervical cancer mortality in China from 1989 to 2018: an age-period-cohort study and Joinpoint analysis.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic and diagnostic value of circRNA expression in cervical cancer: a meta analysis.Frontiers in oncology · 2024Pooled it
- Pooled it
- Safety and immunogenicity of a bivalent HPV16/18 vaccine in Chinese females.Human vaccines & immunotherapeutics · 2023Trial
- Changes in HPV vaccine hesitancy and influencing factors among female university students in China: A national repeated study.Human vaccines & immunotherapeutics · 2026Article
- Analysis and simulation for a two-sex transmission model of HPV infection in Xinjiang of China.Infectious Disease Modelling · 2026Article
- Differential diagnostic value of PAX1 and JAM3 methylation for cervical intraepithelial neoplasia between premenopausal and postmenopausal women: a retrospective clinical study in China.Annals of medicine · 2026Article
- KIF20A promotes cervical cancer progression by interacting with CLIP1.Scientific reports · 2026Article
- Article
- The Epidemiology of colorectal cancer in Guangzhou, China: A cross-sectional and age-period-cohort study.PLOS global public health · 2026Article
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- Urgent need for inclusion of male infertility in global health strategies: insights from the GBD 2021 Study.Asian journal of andrology · 2026Article
- Analysis and comparison of the trends in the burden of motor neuron disease in China and worldwide from 1990 to 2021.PloS one · 2026Article
- Correlation between atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion and cervical lesions: a retrospective analysis of opportunistic and organized cervical screening populations.Frontiers in oncology · 2026Article
- Burden of prostate cancer in China during 1990-2021 and the projections through 2050.Prostate international · 2025Article
- Trend dynamics of mumps prevalence among children aged 1-9 years in Changzhou, 2005-2023: a joinpoint regression and age-period-cohort analysis.BMC public health · 2025Article
- Global, regional, and national burden of hip osteoarthritis (1992-2021) and predictions of future disease burden trends: a systematic analysis of the global burden of disease study 2021.BMC musculoskeletal disorders · 2025Article
- Global Burden and Incidence Trends in Cancers Associated with Human Papillomavirus Infection: A Population-Based Systematic Study.Pathogens (Basel, Switzerland) · 2025Article
- A novel non-invasive mRNA-lncRNA biomarker panel for accurate prediction of cervical squamous cell carcinoma and adenocarcinoma.Journal of gynecologic oncology · 2025Article
- Assessment of magnetic resonance image compilation (MAGiC) abilities of therapeutic selection and prediction on recurrence risk factors and short-term treatment efficacy in cervical cancer.La Radiologia medica · 2025Article
- How delays in seeking medical care for cervical cancer patients are affected by their health-seeking behaviour: a qualitative study.BMC public health · 2025Article
24 more citing papers are in PubMed but not listed here.
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Abstract
backgroundWorldwide, cervical cancer is the second-most-common malignancy of the female reproductive system. Due to its large population, China accounted for 11.9% of cervical cancer deaths, and 12.3% of global cervical cancer DALYs in 2017. In 2009, China launched a nationwide screening program, yet mortality from cervical cancer has shown an upward trend in recent years. The aim of this study was to explore factors affecting cervical cancer mortality rates in China, and contribute to their future reduction.
methodsIn this descriptive study, a Joinpoint regression analysis and age-period-cohort (APC) model based on the intrinsic estimator (IE) algorithm were utilized. Data from the period 1989-2018 were extracted from the International Agency for Research on Cancer (IARC) Database of WHO (1989-2000) and China Health Statistical Yearbook database (2002-2018).
resultsOur study found mortality from cervical cancer to have initially declined, but increase thereafter over the entire observation period in both rural and urban China. The influence of age, period and cohort effect on the mortality rate had statistical significance. The effect of age increased with years, becoming a contributing factor in women aged over 45 years countrywide. Conversely, the cohort effect became a protective factor for women born after 1938 in urban areas, and for women born after 1958 in rural areas. The period effect was relatively less impactful.
conclusionsThe study indicates that organized cervical screening projects facilitated the identification of potential patients, or patients with comorbidities. Correspondingly, mortality was found to increase with incidence, particularly among elderly women, indicating that newly diagnosed patients were at an advanced stage of cervical cancer, or were not receiving appropriate treatment. Therefore, the coverage of cervical cancer screening should be improved, and women's health awareness promoted. Early diagnosis and treatment is critical to reduce the disease burden and improve outcomes.
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