ArticleThe journal of headache and pain2021
Age-related differences in resting state functional connectivity in pediatric migraine.
Article in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Effect of a Mindfulness-Based Intervention for Chronic Migraine and High Frequency Episodic Migraine in Adolescents: A Pilot Single-Arm Open-Label Study.International journal of environmental research and public health · 2021Trial
- [Gender differences in children and adolescents with migraine].Schmerz (Berlin, Germany) · 2026Review
- Multiplatform Morphometric Profiling of Whole-Brain, Cerebellar Subregional, and Thalamic Nuclei Alterations in Pediatric Migraine Without Aura.Diagnostics (Basel, Switzerland) · 2026Article
- Longitudinal changes in neurometabolites in pediatric migraine across child development: a pilot study.Scientific reports · 2026Article
- Cognitive and Neurobiological Correlates for Switching/Inhibition Moderate the Relations Between Word Reading and Reading Comprehension in Hebrew-Speaking Children: An fMRI Study.Dyslexia (Chichester, England) · 2025Article
- Increased MRI-based Brain Age in chronic migraine patients.The journal of headache and pain · 2023Article
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Resting State Functional Connectivity between Dorsal Attentional Network and Right Inferior Frontal Gyrus in Concussed and Control Adolescents.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMigraine affects roughly 10% of youth aged 5-15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains of adult migraine sufferers. This study aims to investigate the effects of migraine on resting-state functional connectivity during the period of transition from childhood to adolescence, a critical period of brain development and the time when rates of pediatric chronic pain spikes.
methodsUsing independent component analysis, we compared resting state network spatial maps and power spectra between youth with migraine aged 7-15 and age-matched controls. Statistical comparisons were conducted using a MANCOVA analysis.
resultsWe show (1) group by age interaction effects on connectivity in the visual and salience networks, group by sex interaction effects on connectivity in the default mode network and group by pubertal status interaction effects on connectivity in visual and frontal parietal networks, and (2) relationships between connectivity in the visual networks and the migraine cycle, and age by cycle interaction effects on connectivity in the visual, default mode and sensorimotor networks.
conclusionsWe demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments.
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